Halo Nevus

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Halo Nevus

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Halo nevi are common benign skin lesions that represent melanocytic nevi in which an inflammatory infiltrate develops, resulting in a zone of depigmentation surrounding the nevus. Although Sutton originally described the lesion in 1916 as leukoderma acquisita centrifugum, the lesions were noted earlier, as evidenced by their depiction in the painting The Temptation of Saint Anthony by Matthias Grünwald circa 1512-1516. [1]

Because melanoma that has undergone regression may appear gray or white, halo nevi have been erroneously confused with melanoma and have been the source of much anxiety among both clinicians and patients. Nevertheless, they are entirely benign lesions and of only cosmetic significance.

The etiology is unknown, but halo nevus is believed to be due to an immune response against melanocytes. Numerous studies have attempted to unravel the immunologic mechanisms by which an immune response develops to existing aggregates of nevus cells. [2] The infiltrating cells are predominantly T-lymphocytes, and cytotoxic (CD8) lymphocytes outnumber helper (CD4) lymphocytes by a ratio of approximately 4:1. These, as well as scattered macrophages, comprise most inflammatory cells in halo nevi. [3] As seen in vitiligo, melanocytes in the epidermis in the halo component of the nevus are completely absent, suggesting a similar etiologic mechanism. [4]  A distinct relationship seems exist that distinguishes halo nevus in patients without vitiligo and halo nevus in patients with vitiligo, although definitive features have not been determined. Multiple halo nevi, the presence of Koebner phenomenon, and a family history of vitiligo have been identified as possibly increasing the risk of vitiligo in patients with halo nevi. [5] The exact role that the lymphocytes play in the regression of halo nevi has not been fully determined, although a theory of direct cytotoxic effects on melanocytes seems plausible.

Of interest, circulating antibodies to the cytoplasm of melanoma cells have been detected in patients with halo nevi. [6] Because these antibodies have disappeared after removal of the halo nevus, they were thought to be related. Subsequent investigation failed to reveal a temporal relation between the appearance of these antibodies and the regression of nevus cells, and these antibodies are now believed to appear as a consequence of the release of cytoplasmic proteins of halo nevus melanocytes secondary to cell damage.

Ultrastructurally, advanced lesions of halo nevus show dermal macrophages containing portions of nevus cells. While it is clear that an immunologic mechanism results in the demise of melanocytes in halo nevi, the precipitating cause and the exact role of the lymphocytes remain unknown. [7]

The incidence of halo nevi in the population is estimated to be 1%. [8] Patients with Turner syndrome have been reported to have an increased incidence of halo nevi. [9]

All races are susceptible to the development of these lesions. A familial tendency for halo nevi has been reported.

No sexual predilection is reported.

Halo nevi are found most commonly in children. [10] The average age of onset is 15 years.

Halo nevi are benign. Morbidity is minimal and limited to cosmetic appearance. Because halo nevi are benign, the prognosis for patients is excellent.

Patients should be instructed to monitor the lesion. If changes occur that suggest irregularity or if such symptoms as bleeding, itching, pain, or ulceration develop, the patient should be reevaluated promptly to exclude the possibility of cutaneous melanoma. For patient education resources, see the patient education article Mole Removal.

Happle R. [Grunewald nevus]. Hautarzt. 1994 Dec. 45(12):882-3. [Medline].

Zeff RA, Freitag A, Grin CM, Grant-Kels JM. The immune response in halo nevi. J Am Acad Dermatol. 1997 Oct. 37(4):620-4. [Medline].

Patrizi A, Neri I, Sabattini E, Rizzoli L, Misciali C. Unusual inflammatory and hyperkeratotic halo naevus in children. Br J Dermatol. 2005 Feb. 152(2):357-60. [Medline].

van Geel N, Vandenhaute S, Speeckaert R, et al. Prognostic value and clinical significance of halo naevi regarding vitiligo. Br J Dermatol. 2011 Apr. 164(4):743-9. [Medline].

Zhou H, Wu LC, Chen MK, Liao QM, Mao RX, Han JD. Factors Associated with Development of Vitiligo in Patients with Halo Nevus. Chin Med J (Engl). 2017 Nov 20. 130 (22):2703-2708. [Medline].

Fishman HC. Letter: Malignant melanoma arising with two halo nevi. Arch Dermatol. 1976 Mar. 112(3):407-8. [Medline].

Jacobs JB, Edelstein LM, Snyder LM, Fortier N. Ultrastructural evidence for destruction in the halo nevus. Cancer Res. 1975 Feb. 35(2):352-7. [Medline].

Herd RM, Hunter JA. Familial halo naevi. Clin Exp Dermatol. 1998 Mar. 23(2):68-9. [Medline].

Brazzelli V, Larizza D, Martinetti M, et al. Halo nevus, rather than vitiligo, is a typical dermatologic finding of turner’s syndrome: clinical, genetic, and immunogenetic study in 72 patients. J Am Acad Dermatol. 2004 Sep. 51(3):354-8. [Medline].

Jalalabadi F, Trost JG, Cox JA, Lee EI, Pourciau CY. Common Pediatric Skin Lesions: A Comprehensive Review of the Current Literature. Semin Plast Surg. 2016 Aug. 30 (3):91-7. [Medline].

Zalaudek I, Moscarella E, Argenziano G. Artifactual “pseudo-halo nevi” secondary to sunscreen application. J Am Acad Dermatol. 2006 Jun. 54(6):1106-7. [Medline].

Berg P, Lindelof B. Differences in malignant melanoma between children and adolescents. A 35-year epidemiological study. Arch Dermatol. 1997 Mar. 133(3):295-7. [Medline].

Halo Nevus

Melanoma

Nevus cells in nests

Single atypical melanocytes at all levels of the epidermis and aggregates of atypical melanocytes in the dermis

Lesion symmetrical

Lesion asymmetrical

Maturation of nevus cells

Lack of maturation

Mitotic figures rare or absent

Mitotic figures present

Lymphocytic infiltrate present diffusely throughout lesion

Lymphocytic infiltrate tends to be at be concentrated at periphery

Edward J Zabawski, Jr, DO Medical and Surgical Dermatology

Edward J Zabawski, Jr, DO is a member of the following medical societies: American Osteopathic Association, New England Dermatological Society

Disclosure: Nothing to disclose.

Clay J Cockerell, MD Director, Clinical Professor, Department of Dermatology, Division of Dermatopathology, University of Texas Southwestern Medical Center

Clay J Cockerell, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, International AIDS Society, International Academy of Pathology, International Society for Dermatologic Surgery, North American Clinical Dermatologic Society, Society for Investigative Dermatology, Southern Medical Association

Disclosure: Nothing to disclose.

Richard P Vinson, MD Assistant Clinical Professor, Department of Dermatology, Texas Tech University Health Sciences Center, Paul L Foster School of Medicine; Consulting Staff, Mountain View Dermatology, PA

Richard P Vinson, MD is a member of the following medical societies: American Academy of Dermatology, Texas Medical Association, Association of Military Dermatologists, Texas Dermatological Society

Disclosure: Nothing to disclose.

Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine

Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology

Disclosure: Nothing to disclose.

Susan M Swetter, MD Director, Pigmented Lesion and Melanoma Program, Professor, Department of Dermatology, Stanford University Medical Center and Cancer Institute, Veterans Affairs Palo Alto Health Care System

Susan M Swetter, MD is a member of the following medical societies: American Academy of Dermatology, Women’s Dermatologic Society, American Society of Clinical Oncology, Society for Melanoma Research, Eastern Cooperative Oncology Group, American Medical Association, Pacific Dermatologic Association, Society for Investigative Dermatology

Disclosure: Nothing to disclose.

Halo Nevus

Research & References of Halo Nevus|A&C Accounting And Tax Services
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From Admin and Read More here. A note for you if you pursue CPA licence, KEEP PRACTICE with the MANY WONDER HELPS I showed you. Make sure to check your works after solving simulations. If a Cashflow statement or your consolidation statement is balanced, you know you pass right after sitting for the exams. I hope my information are great and helpful. Implement them. They worked for me. Hey.... turn gray hair to black also guys. Do not forget HEALTH? Skill Progression is certainly the number 1 critical and most important matter of acquiring valid achievements in most professionals as you actually discovered in a lot of our the community and even in Globally. Which means that fortunate to talk about together with everyone in the following relating to just what exactly effective Ability Enhancement is;. ways or what strategies we operate to gain dreams and in due course one will certainly succeed with what anybody is in love with to perform each working day intended for a maximum everyday living. Is it so superb if you are in a position to acquire proficiently and find financial success in whatever you believed, targeted for, self-displined and worked well very hard every single day time and without doubt you come to be a CPA, Attorney, an entrepreneur of a great manufacturer or perhaps even a health practitioner who will be able to greatly add superb benefit and principles to people, who many, any world and community certainly admired and respected. I can's think I can benefit others to be top notch specialized level exactly who will lead critical methods and help values to society and communities at this time. How delighted are you if you turn out to be one like so with your personal name on the headline? I have got there at SUCCESS and rise above almost all the very hard areas which is passing the CPA tests to be CPA. Moreover, we will also protect what are the dangers, or several other issues that is perhaps on your means and precisely how I have personally experienced all of them and could reveal you learn how to beat them.

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Halo Nevus

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