Malignant peripheral nerve sheath tumors

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Malignant peripheral nerve sheath tumors

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Malignant peripheral nerve sheath tumors are a rare type of cancer that occurs in the lining of the nerves that extend from the spinal cord into the body. Malignant peripheral nerve sheath tumors used to be called neurofibrosarcomas.

Malignant peripheral nerve sheath tumors can occur anywhere in the body, but most often occur in the deep tissue of the arms, legs and trunk. They tend to cause pain and weakness in the affected area and may also cause a growing lump or mass.

Malignant peripheral nerve sheath tumors are typically treated with surgery. In certain cases, radiation therapy and chemotherapy also may be recommended.

Signs and symptoms of malignant peripheral nerve sheath tumors include:

Make an appointment with your doctor if you have any persistent signs and symptoms that worry you. Malignant peripheral nerve sheath tumors are rare, so your doctor may investigate more-common causes for your symptoms.

It’s not clear what causes most malignant peripheral nerve sheath tumors.

Doctors know that these cancers begin when a cell in the protective lining around a nerve develops an error (mutation) in its DNA. The mutation tells the cell to multiply rapidly and to continue living when other cells would normally die. The accumulating cells form a tumor that can grow to invade nearby tissue or spread to other areas of the body.

Factors that increase the risk of malignant peripheral nerve sheath tumors include:

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Malignant peripheral nerve sheath tumors

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Malignant peripheral nerve sheath tumors

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