Mixed connective tissue disease
Find out why Mayo Clinic is the right place for your health care. Make an appointment..
Find a directory of doctors and departments at all Mayo Clinic campuses. Visit now..
See how Mayo Clinic research and clinical trials advance the science of medicine and improve patient care. Explore now..
Educators at Mayo Clinic train tomorrow’s leaders to deliver compassionate, high-value, safe patient care. Choose a degree..
Explore Mayo Clinic’s many resources and see jobs available for medical professionals. Get updates..
Your support accelerates powerful innovations in patient care, research and education. Give today..
Mixed connective tissue disease has signs and symptoms of a combination of disorders — primarily lupus, scleroderma and polymyositis. For this reason, mixed connective tissue disease is sometimes referred to as an overlap disease.
In mixed connective tissue disease, the symptoms of the separate diseases usually don’t appear all at once. Instead, they tend to occur in sequence over a number of years, which can make diagnosis more complicated.
Early signs and symptoms often involve the hands. Fingers might get puffy, and the fingertips become white and numb, often in response to cold exposure. In later stages, some organs — such as the lungs, heart and kidneys — may be affected.
There’s no cure for mixed connective tissue disease. The signs and symptoms are usually treated with certain medications, such as prednisone.
Early indications of mixed connective tissue disease can include:
See your doctor if you have signs and symptoms that interfere with your daily routine — particularly if you’ve already been diagnosed with lupus or another connective tissue disease.
The precise cause of mixed connective tissue disease isn’t known.
Mixed connective tissue disease is an autoimmune disorder. In autoimmune disorders, your immune system — responsible for fighting off disease — mistakenly attacks healthy cells.
In connective tissue diseases, your immune system attacks the fibers that provide the framework and support for your body. Researchers are working to identify proteins produced by the immune system that might cause mixed connective tissue disease.
Some people with mixed connective tissue disease have a family history of the condition. But the role of genetics in causing the disease remains unclear.
Mixed connective tissue disease can occur in people of any age. However, it appears to be most common in women under the age of 50.
Mixed connective tissue disease can lead to serious complications, including:
Corticosteroids are commonly used to manage the signs and symptoms of mixed connective tissue disease. These medications are effective, but they carry risks.
Your doctor will likely monitor you for adverse effects, such as osteoporosis, muscle weakness and infection. You may need to take calcium and vitamin D supplements to help ease these adverse effects.
Mayo Clinic does not endorse companies or products. Advertising revenue supports our not-for-profit mission.
Check out these best-sellers and special offers on books and newsletters from Mayo Clinic.
A single copy of these materials may be reprinted for noncommercial personal use only. “Mayo,” “Mayo Clinic,” “MayoClinic.org,” “Mayo Clinic Healthy Living,” and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.
Mixed connective tissue disease
Research & References of Mixed connective tissue disease|A&C Accounting And Tax Services