17-Ketosteroids 

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17-Ketosteroids 

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The reference range of urinary 17-ketosteroids is as follows [1] :

Males: 10-20 mg (34-69 µmol)/24 h

Females: 5-15 mg (17-52 µmol)/24 h

Increases in levels of 24-hour urinary 17-ketosteroids are associated with the following:

Adrenal tumors

Cushing syndrome

Ovarian cancer

Testicular cancer

Polycystic ovarian syndrome

Congenital adrenal hyperplasia (rare)

Decreases in levels of 24-hour urinary 17-ketosteroids are associated with the following:

Addison disease

Hypopituitarism

Myxedema

Nephrosis

Castration

Specifics for collection and panels are as follows:

Specimen type: Urine (see image below)

Collection method: 24-hour urine collection

Other instructions: Record duration and total volume

The 17-ketosteroids are breakdown products of androgens. Examples of 17-ketosteroids include androstenedione, androsterone, estrone, and dehydroepiandrosterone.

Newer tests have superseded 17-ketosteroid testing, and the assay is seldom used now.

Drugs that can increase 17-ketosteroids measurements include the following:

Antibiotics (eg, penicillin, oxacillin)

Chlorpromazine

Ethinamate

Meprobamate

Phenaglycodol

Nalidixic acid

Spironolactone

Drugs that can decrease 17-ketosteroids measurements include the following:

Progestational agents

Carbamazepine

Cephalothin

Propoxyphene

Reserpine

Glucose

Chlordiazepoxide

Zumoff B, Rosenfeld RS, Strain GW, Levin J, Fukushima DK. Sex differences in the twenty-four-hour mean plasma concentrations of dehydroisoandrosterone (DHA) and dehydroisoandrosterone sulfate (DHAS) and the DHA to DHAS ratio in normal adults. J Clin Endocrinol Metab. 1980 Aug. 51(2):330-3. [Medline].

McPherson RA, Pincus MR. Henry’s Clinical Diagnosis and Management by Laboratory Methods. 22nd ed. Philadelphia: Elsevier Saunders; 2011.

Williamson MA, Snyder LM, eds. Wallach’s Interpretation of Diagnostic Tests. 9th ed. Philadelphia, Pa: Lippincott Williams & Wilkins; 2011.

Rajaa Almourani, MD Resident Physician, Department of Internal Medicine, St Louis University Hospital

Rajaa Almourani, MD is a member of the following medical societies: National Arab American Medical Association, Syrian American Medical Society

Disclosure: Nothing to disclose.

Thomas M Wheeler, MD Chairman, Department of Pathology and Immunology, WL Moody, Jr, Professor of Pathology, Professor of Urology, Baylor College of Medicine

Thomas M Wheeler, MD is a member of the following medical societies: Alpha Omega Alpha, American Association for Cancer Research, American Medical Association, American Society for Clinical Pathology, American Society of Cytopathology, American Thyroid Association, American Urological Association, College of American Pathologists, United States and Canadian Academy of Pathology, International Society of Urological Pathology, Harris County Medical Society

Disclosure: Received stock from PathXL for medical advisory board. for: PathXL, Inc.

Judy Lin, MD

Disclosure: Nothing to disclose.

17-Ketosteroids 

Research & References of 17-Ketosteroids |A&C Accounting And Tax Services
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