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Trending Clinical Topic: Warfarin
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Ryan Syrek
November 01, 2019
Each week, we identify one top search term, speculate as to what caused its popularity, and provide an infographic on a related condition. If you have thoughts about what’s trending and why, feel free to share them with us on Twitter or Facebook.
Results of a study on treatment for atrial fibrillation (AF) and new findings regarding treatment for antiphospholipid syndrome (APS) put a focus on warfarin this week, making it the top trending clinical topic. A study published in the Journal of the American College of Cardiology found that direct-acting oral anticoagulants (DOACs) for AF are associated with a lower risk for osteoporotic fractures compared with warfarin. Results from the 2-year study of more than 37,000 patients with AF found a significantly reduced relative risk for any fracture or for starting on osteoporosis medication. This prompted the authors to conclude that clinicians should consider switching treatments in patients taking warfarin who are at risk for osteoporosis or osteoporotic fractures. However, an accompanying editorial suggested that the choice between warfarin or a DOAC in patients with AF and no prior osteoporotic fracture (the population studied) shouldn’t be made on the basis of risk for osteoporotic fracture but on other risks, including ischemic stroke and hemorrhage, as well as the need for monitoring and drug affordability.
Alternatively, a randomized study published in the Annals of Internal Medicine showed that warfarin was superior to rivaroxaban for anticoagulant treatment used to address thrombosis in patients with APS. In fact, patients with APS who were treated with rivaroxaban demonstrated nearly double the risk for recurrent thrombosis than patients treated with warfarin. One patient in the rivaroxaban group developed catastrophic APS. Proposed guidelines by the European League Against Rheumatism recommend against use of rivaroxaban in patients with triple-positive APS, and these findings appear to support that guidance. These additional pieces of evidence regarding the best approaches for the use of warfarin in different patient groups helped make the drug this week’s top trending clinical topic.
Read more about the uses and adverse effects of warfarin.
Medscape © 2019 WebMD, LLC
Any views expressed above are the author’s own and do not necessarily reflect the views of WebMD or Medscape.
Cite this: Ryan Syrek. Trending Clinical Topic: Warfarin – Medscape – Nov 01, 2019.
Senior Editor, Medical Students, Medscape Drugs & Diseases
Disclosure: Ryan Syrek has disclosed no relevant financial relationships.
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Trending Clinical Topic: Warfarin
Research & References of Trending Clinical Topic: Warfarin|A&C Accounting And Tax Services
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A note for you if you pursue CPA licence, KEEP PRACTICE with the MANY WONDER HELPS I showed you. Make sure to check your works after solving simulations. If a Cashflow statement or your consolidation statement is balanced, you know you pass right after sitting for the exams. I hope my information are great and helpful. Implement them. They worked for me. Hey.... turn gray hair to black also guys. Do not forget HEALTH?
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