Emergent Management of Acute Otitis Media
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One consideration in the emergent management of acute otitis media (AOM) is that diagnostic certainty for the disease is based on all 3 of the following criteria, as set forth by the American Academy of Pediatrics (AAP) and the American Academy of Family Physicians (AAFP): acute onset, middle ear effusion (MEE), and middle ear inflammation.
Severe illness is defined as moderate to severe otalgia or temperature greater than 39°C, whereas nonsevere illness is defined as mild otalgia and temperature less than 39°C. AOM most commonly occurs in children and is the most frequent specific diagnosis in children who are febrile. Clinicians often overdiagnose AOM. Recurrent AOM is defined as 3 episodes within 6 months or 4 or more episodes within 1 year.
Distinguishing between AOM and otitis media with effusion (OME) is important. OME is more common than AOM. When OME is mistaken for AOM, antibiotics may be prescribed unnecessarily. OME is fluid in the middle ear without signs or symptoms of infection. It is usually caused when the eustachian tube is blocked and fluid becomes trapped in the middle ear. Signs and symptoms of AOM occur when fluid in the middle ear becomes infected. (See the images below.)
A retrospective study by Mattos et al of 109 children with AOM found that complications of the disorder and their rates of occurrence include the following [1] :
Mastoiditis (86.1%)
Subperiosteal abscess (38%)
Facial nerve palsy (16.7%)
Sigmoid sinus thrombosis (8.3%)
Epidural abscess (7.4%)
Other: Postauricular cellulitis, internal jugular thrombosis, sensorineural hearing loss, otic hydrocephalus and elevated intracranial pressure, cranial nerve VI palsy and Gradenigo syndrome, cerebellar infarct, and labyrinthine fistula
Insufflation, tympanometry, and acoustic reflexometry are helpful to identify the presence or absence of MEE. Of these, insufflation is the only one commonly used in the emergency department (ED) setting. Tympanometry and acoustic reflexometry cannot be recommended as a routine screening test for acute otitis media (AOM). However, in a patient in whom examination is difficult, normal tympanometric results may help to rule out AOM.
Nasopharyngoscopy may reveal anatomic factors involved in AOM and show purulent matter at the nasal opening of the eustachian tube, but the findings are of no acute diagnostic value.
No definitive laboratory examination exists for AOM, and hearing tests are not helpful in diagnosing the condition. Radiography and/or computed tomography (CT) scanning of the mastoid air cells may be helpful in select cases of suspected mastoiditis, but imaging studies are not valuable for diagnosis of AOM.
Tympanocentesis, myringotomy, or both may be appropriate to delineate the etiology of AOM in an immunocompromised patient, a patient with mastoiditis, [2] a patient with persistent fever in the face of antibiotic therapy, or a patient with intractable pain. If AOM is present in infants younger than 2-3 months, some authors recommend tympanocentesis. These procedures often are performed by the ear, nose, and throat (ENT) consultant. In the event that a tympanocentesis is performed, a sample of the effusion should be sent for culture and sensitivity. [3]
A 2013 update to guidelines from the AAP and the AAFP recommends the following criteria for the diagnosis of AOM in children [4] :
Clinicians should diagnose AOM in children who present with moderate to severe bulging of the tympanic membrane (TM) or new onset of otorrhea not due to acute otitis externa; evidence quality: grade B
Clinicians may diagnose AOM in children who present with mild bulging of the TM and recent (less than 48 hours) onset of ear pain (holding, tugging, rubbing of the ear in a nonverbal child) or intense erythema of the TM; evidence quality: grade C
Clinicians should not diagnose AOM in children who do not have middle ear effusion (MEE) (based on pneumatic otoscopy and/or tympanometry); evidence quality: grade B
As previously mentioned, diagnostic certainty in acute otitis media (AOM) is based on all 3 of the following criteria: acute onset, MEE, and middle ear inflammation. Severe illness is defined as moderate-to-severe otalgia or temperature greater than 39°C, whereas nonsevere illness is defined as mild otalgia and temperature less than 39°C.
Although the definition of AOM is relatively uniform, the diagnosis is not always as clear. It is this diagnostic uncertainty that may lead to overdiagnosis and unnecessary antibiotic use or to underdiagnosis and an increase in complications. Overdiagnosis of AOM is frequently a result of all of the following:
Difficulty in differentiating AOM from OME
Difficulty in confirming Mee
Poor compliance with guidelines for diagnosis
Several studies have demonstrated the difficulty and inconsistency with which practitioners diagnose AOM. [5, 6] In a study of interrater agreement on AOM in children, Blomgren et al noted a substantial discrepancy concerning practitioner impressions of the tympanic membrane. The clinicians agreed on only 64% of the diagnoses of AOM. The use of a pneumatic otoscopy and tympanometry reduces the number of AOM diagnoses by greater than 30%, suggesting that AOM is misdiagnosed often. [7, 8]
The May 2004 AAP/AAFP clinical practice guidelines for the management of AOM in children aged 6 months to 12 years recommend that infants younger than age 6 months receive antibiotics and that children aged 6 months to 2 years receive antibiotics if the diagnosis is certain. (See Table 1.)
Children aged 2 years and older should receive antibiotics if the diagnosis is certain and if the illness is severe. If the diagnosis is uncertain, an observation period can be considered if the illness is nonsevere, and antibiotic therapy can be considered for severe illness.
According to AAP/AAFP guidelines, an observation period may be recommended depending on the patient’s age, the diagnostic certainty, and the severity of illness. [9] An observation period is an option when the diagnosis is uncertain or when it is certain and nonsevere. The observation option is a 48-hour to 72-hour period of symptomatic treatment with analgesics and without antibiotics.
For an observation option to be considered, the parent or caregiver must be able to communicate with the clinician and have access to follow-up care whenever problems ensue or symptoms worsen. Studies in the ED setting have shown that the observation option is feasible and well accepted. [10, 11]
If prescribed antibiotics, children younger than age 2 years and those aged 2-5 years with severe disease should receive 10 days of therapy. For those who are age 6 years or older with mild to moderate disease, 5-7 days is appropriate.
Pain management is an important part of treating AOM. Appropriate analgesics should be offered.
The aforementioned 2013 update to the AAP/AAFP guidelines includes the following recommendations regarding the care of pediatric patients with AOM [4] :
The management of AOM should include an assessment of pain; if pain is present, the clinician should recommend treatment to reduce pain; evidence quality: grade B
Severe AOM: The clinician should prescribe antibiotic therapy for AOM (bilateral or unilateral) in children aged 6 months or older with severe signs or symptoms (ie, moderate or severe otalgia, otalgia for at least 48 hours, or temperature of 102.2°F or higher); evidence quality: grade B
Nonsevere bilateral AOM in young children: The clinician should prescribe antibiotic therapy for bilateral AOM in children aged 6 months through 23 months without severe signs or symptoms (ie, mild otalgia for less than 48 hours and temperature of less than 102.2°F); evidence quality: grade B
Nonsevere unilateral AOM in young children: The clinician should either prescribe antibiotic therapy or offer observation with close follow-up based on joint decision-making with the parent(s)/caregiver for children aged 6-23 months of age with unilateral AOM without severe signs or symptoms (ie, mild otalgia for less than 48 hours and temperature less than 102.2°F); evidence quality: grade B
Nonsevere AOM in older children: The clinician should either prescribe antibiotic therapy or offer observation with close follow-up based on joint decision-making with the parent(s)/caregiver for children aged 24 months or older with AOM (bilateral or unilateral) without severe signs or symptoms (ie, mild otalgia for less than 48 hours and temperature less than 102.2°F); evidence quality: grade B
Studies have also shown that, despite adequate access to clinical guidelines, the prescribing rates for antibiotics in acute otitis media (AOM) in some emergency departments remain high. [12, 13] (In accordance with the guidelines, however, administration of amoxicillin and analgesics has increased.) [14]
Table 1. Criteria for Initial Antibacterial Agent Treatment or Observation in Children With Acute Otitis Media [15] (Open Table in a new window)
Age
Certain Diagnosis
Uncertain Diagnosis
< 6 mo
Antibacterial therapy
Antibacterial therapy
6 mo–2 y
Antibacterial therapy
Antibacterial therapy if severe illness; observation option* if nonsevere illness
≥2 y
Antibacterial therapy if severe illness; observation option* if nonsevere illness
Observation option*
*Observation is an appropriate option only when follow-up can be ensured and antibacterial agents started if symptoms persist or worsen. Nonsevere illness is mild otalgia and fever of less than 39°C in the previous 24 hours. Severe illness is moderate to severe otalgia or fever greater than or equal to 39°C. A certain diagnosis of AOM meets all 3 criteria: (1) rapid onset, (2) signs of MEE, and (3) signs and symptoms of middle-ear inflammation. [15]
Studies have shown that antibiotics provide little benefit beyond placebo in mild cases of acute otitis media (AOM).
Infants with frequent recurrences of AOM may be considered for daily antibiotic prophylaxis with sulfamethoxazole or amoxicillin for a period of several months. However, the decrease in frequency of recurrent episodes is small to none. [16, 17]
The potential consequences of excessive antibiotic use are well known, and newer recommendations are that antibiotic prophylaxis for AOM should be avoided whenever possible.
If antibiotic therapy is chosen, the AAP and FAAP recommend that amoxicillin 80-90 mg/kg/d is the antibiotic of choice. The length of treatment is 10 days for younger children and patients with severe illness, otherwise, a 5- to 7-day course is appropriate.
If additional beta-lactamase-positive Haemophilus influenzae and/or Moraxella catarrhalis coverage is desired, the administration of high-dose amoxicillin and clavulanate potassium is recommended.
If the patient is allergic to amoxicillin, alternatives are cefdinir, cefpodoxime, or cefuroxime if the allergic reaction is not a type 1 hypersensitivity. Patients with type 1 hypersensitivity should be given azithromycin or clarithromycin.
Ceftriaxone injection (50 mg/kg/d) is recommended for children who are unable to take oral antibiotics and for patients with compliance problems. However, a single injection of ceftriaxone is insufficient against nonsusceptible pneumococci, with a bacteriologic failure rate of approximately 40%. [18] In patients whose condition fails to improve after initial antibiotic therapy, a 3-day course of ceftriaxone offers outcomes better than those of a 1-day course.
When prescribing antibiotics to the pediatric population, one also has to consider the probability of noncompliance to therapy. In this age group, the palatability of a drug may influence adherence to treatment. If prescribing cephalosporins, consider the use of cefdinir (Omnicef), as it has a more accepted taste when compared with the other recommended cephalosporins (eg, cefuroxime). [19]
Topical quinolones are the preferred agents for the treatment of AOM in children with tympanostomy tubes (AOMT) and/or perforations. The treatment options for AOMT, as discussed in a clinical review by Schmelzle et al, include systemic or topical antibiotics. [20] Topical treatment with fluoroquinolones is superior to that with systemic antibiotics and results in less antibiotic resistance and fewer adverse effects (ototoxicity) than do other treatments.
Because of potential ototoxicity, topical aminoglycosides should be avoided and not used to treat the draining ear. [20]
The management of AOM should always include assessment of pain and fever. Antipyretics and analgesics may be necessary and should be prescribed liberally.
The addition of dexamethasone to a topical antibiotic may decrease the length of time necessary for middle ear drainage when compared with a topical antibiotic alone. The evidence for superior outcomes with the addition of steroids lacks strength; plus, the addition of steroids exacerbates overall treatment costs, and this may lead to nonadherence to treatment. [20]
Steroids, decongestants, and antihistamines are not effective in the treatment of AOM and may instead cause complications.
Several complementary and/or alternative medicine (CAM) therapies, such as homeopathy, acupuncture, herbal remedies, chiropractic treatments, and nutritional supplements, have been used by parents/caregivers for the treatment of AOM. The preferred therapy is largely dependent on cultural background and/or practices. Data supporting complementary and alternative therapies are limited and controversial. Currently, there are no recommendations for the use of CAM for the treatment of AOM. [15]
Most cases of otitis media are self-limited. If the signs and symptoms of acute otitis media (AOM) are resolved, patients should follow up with their primary care provider (PCP) in 4-6 weeks to evaluate for persistent OME. In addition, patients discharged with or without antibiotic therapy should be reexamined 4-6 weeks after their initial presentation for evidence of middle ear aeration.
Patients whose symptoms (eg, pain, fever) do not resolve within 48-72 hours of treatment should be reevaluated. Patients with persistent symptoms or recurrent AOM should be referred to an otorhinolaryngologist for evaluation and possible tympanocentesis. If antibiotics were started initially and if the patient’s condition fails to improve, the antibiotic should be changed, and compliance must be emphasized.
If an observation period is chosen, failure to improve within 48-72 hours should prompt initiation of antibiotic therapy.
A study by Hendrickson et al of follow-up preferences among PCPs and emergency medicine providers (EMCs) in a regional health system found that for patients with upper respiratory tract infection or AOM, PCPs were more likely than EMCs to direct patients to pursue as-needed follow-up rather than definite follow-up. [21]
Mattos JL, Colman KL, Casselbrant ML, Chi DH. Intratemporal and intracranial complications of acute otitis media in a pediatric population. Int J Pediatr Otorhinolaryngol. 2014 Dec. 78 (12):2161-4. [Medline].
Thompson PL, Gilbert RE, Long PF, Saxena S, Sharland M, Wong IC. Effect of antibiotics for otitis media on mastoiditis in children: a retrospective cohort study using the United kingdom general practice research database. Pediatrics. 2009 Feb. 123(2):424-30. [Medline].
Lieberthal AS, Carroll AE, Chonmaitree T, Ganiats TG, Hoberman A, Jackson MA, et al. The diagnosis and management of acute otitis media. Pediatrics. 2013 Mar. 131(3):e964-99. [Medline].
Siddiq S, Grainger J. The diagnosis and management of acute otitis media: American Academy of Pediatrics Guidelines 2013. Arch Dis Child Educ Pract Ed. 2015 Aug. 100 (4):193-7. [Medline]. [Full Text].
Pichichero ME. Diagnostic accuracy, tympanocentesis training performance, and antibiotic selection by pediatric residents in management of otitis media. Pediatrics. 2002 Dec. 110(6):1064-70. [Medline]. [Full Text].
Rosenfeld RM. Diagnostic certainty for acute otitis media. Int J Pediatr Otorhinolaryngol. 2002 Jun 17. 64(2):89-95. [Medline].
Blomgren K, Pitkaranta A. Is it possible to diagnose acute otitis media accurately in primary health care?. Fam Pract. 2003 Oct. 20(5):524-7. [Medline].
Rosenkranz S, Abbott P, Reath J, Gunasekera H, Hu W. Promoting diagnostic accuracy in general practitioner management of otitis media in children: findings from a multimodal, interactive workshop on tympanometry and pneumatic otoscopy. Qual Prim Care. 2012. 20(4):275-85. [Medline].
[Guideline] Neff MJ. AAP, AAFP release guideline on diagnosis and management of acute otitis media. Am Fam Physician. 2004 Jun 1. 69(11):2713-5. [Medline].
Chao JH, Kunkov S, Reyes LB, Lichten S, Crain EF. Comparison of two approaches to observation therapy for acute otitis media in the emergency department. Pediatrics. 2008 May. 121(5):e1352-6. [Medline].
Spiro DM, Tay KY, Arnold DH, Dziura JD, Baker MD, Shapiro ED. Wait-and-see prescription for the treatment of acute otitis media: a randomized controlled trial. JAMA. 2006 Sep 13. 296(10):1235-41. [Medline].
Fischer T, Singer AJ, Lee C, Thode HC Jr. National trends in emergency department antibiotic prescribing for children with acute otitis media, 1996 2005. Acad Emerg Med. 2007 Dec. 14(12):1172-5. [Medline].
Venekamp RP, Sanders SL, Glasziou PP, Del Mar CB, Rovers MM. Antibiotics for acute otitis media in children. Cochrane Database Syst Rev. 2015 Jun 23. 6:CD000219. [Medline].
Coco A, et al. Management of acute otitis media after publication of the 2004 AAP and AAFP clinical practice guideline. Pediatrics. Feb 2010. 125(2):214-220.
[Guideline] American Academy of Pediatrics. Diagnosis and management of acute otitis media. Pediatrics. 2004 May. 113(5):1451-65. [Medline].
Scott FD, et al. Principles of Judicious Use of Antimicrobial Agents. Pediatrics. Jan 1998. 100 (1):165-171. [Full Text].
Roark R, Berman S. Continuous twice daily or once daily amoxicillin prophylaxis compared with placebo for children with recurrent acute otitis media. Pediatr Infect Dis J. 1997 Apr. 16(4):376-81. [Medline].
Pelton S, et al. Recent Advances in Otitis Media. The Pediatric Infectious Disease Journal. Oct 2009. 28(10):S133-S137.
Steele RW, Blumer JL, Kalish GH. Patient, physician, and nurse satisfaction with antibiotics. Clin Pediatr (Phila). 2002 Jun. 41(5):285-99. [Medline].
Schmelzle J, Birtwhistle RV, Tan AK. Acute otitis media in children with tympanostomy tubes. Can Fam Physician. 2008 Aug. 54(8):1123-7. [Medline]. [Full Text].
Hendrickson MA, Obeya E, Wey AR, Gaillard PR. Community Primary Care Provider Preferences for Emergency Department Follow-up Recommendations: A Regional Study. Pediatr Emerg Care. 2017 Mar 9. [Medline].
Age
Certain Diagnosis
Uncertain Diagnosis
< 6 mo
Antibacterial therapy
Antibacterial therapy
6 mo–2 y
Antibacterial therapy
Antibacterial therapy if severe illness; observation option* if nonsevere illness
≥2 y
Antibacterial therapy if severe illness; observation option* if nonsevere illness
Observation option*
*Observation is an appropriate option only when follow-up can be ensured and antibacterial agents started if symptoms persist or worsen. Nonsevere illness is mild otalgia and fever of less than 39°C in the previous 24 hours. Severe illness is moderate to severe otalgia or fever greater than or equal to 39°C. A certain diagnosis of AOM meets all 3 criteria: (1) rapid onset, (2) signs of MEE, and (3) signs and symptoms of middle-ear inflammation. [15]
Brenda L Natal, MD, MPH Assistant Professor of Emergency Medicine, Simulation Director, Rutgers New Jersey Medical School; Attending Physician, Department of Emergency Medicine, University Hospital of Newark
Brenda L Natal, MD, MPH is a member of the following medical societies: American College of Emergency Physicians, American Medical Association
Disclosure: Nothing to disclose.
Jennifer H Chao, MD, FAAP Clinical Associate Professor of Pediatric Emergency Medicine, State University of New York Downstate College of Medicine; Attending Physician, Pediatric Emergency Department, Kings County Hospital and University Hospital Brooklyn
Jennifer H Chao, MD, FAAP is a member of the following medical societies: American Academy of Pediatrics, American College of Emergency Physicians
Disclosure: Nothing to disclose.
Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference
Disclosure: Received salary from Medscape for employment. for: Medscape.
Jeter (Jay) Pritchard Taylor, III, MD Assistant Professor, Department of Surgery, University of South Carolina School of Medicine; Attending Physician, Clinical Instructor, Compliance Officer, Department of Emergency Medicine, Palmetto Richland Hospital
Jeter (Jay) Pritchard Taylor, III, MD is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, American Medical Association, Columbia Medical Society, Society for Academic Emergency Medicine, South Carolina College of Emergency Physicians, South Carolina Medical Association
Disclosure: Serve(d) as a director, officer, partner, employee, advisor, consultant or trustee for: Employed contractor – Chief Editor for Medscape.
Jerry R Balentine, DO, FACEP, FACOEP Vice President, Medical Affairs and Global Health, New York Institute of Technology; Professor of Emergency Medicine, New York Institute of Technology College of Osteopathic Medicine
Jerry R Balentine, DO, FACEP, FACOEP is a member of the following medical societies: American College of Emergency Physicians, New York Academy of Medicine, American College of Osteopathic Emergency Physicians, American Association for Physician Leadership, American Osteopathic Association
Disclosure: Nothing to disclose.
The authors and editors of Medscape Reference gratefully acknowledge the contributions of the previous authors, Kathy A Cook, MD, and Matthew J Walsh, MD, to the development and writing of this article.
Emergent Management of Acute Otitis Media
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