A trial looking at chemotherapy after surgery for colorectal cancer (QUASAR 1)

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A trial looking at chemotherapy after surgery for colorectal cancer (QUASAR 1)

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This trial looked at adjuvantOpen a glossary item chemotherapy for people who have bowel cancer (colorectal cancer) removed with surgery.

Surgery is usually the first treatment for bowel cancer. Some people also have chemotherapy. Doctors thought that this reduced the risk of the cancer coming back, but they were not sure.

The aim of this trial was to see if having drugs called fluorouracil and folinic acidOpen a glossary item after surgery helped to stop stage 1, 2 or 3 colorectal cancer coming back after surgery.

The research team found that chemotherapy could reduce the risk of cancer coming back in people with stage 2 or 3 bowel cancer.

The trial recruited 3,239 people who had bowel cancer that had been completely removed with surgery. Most people taking part had stage 2 bowel cancer. Half the people had chemotherapy, the other half did not (the control groupOpen a glossary item).

When they did their analysis in 2007, the researchers found that cancer had come back in

People in the chemotherapy group had more diarrhoea, sickness, sore mouth, loss of appetite and fatigue than the control group, but only during the time they were having chemotherapy.

We have based this summary on information from the team who ran the trial. The information they sent us has been reviewed by independent specialists (peer reviewedOpen a glossary item) and published in a medical journal. The figures we quote above were provided by the trial team. We have not analysed the data ourselves.

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Dr David Kerr

Cancer Research UK
Medical Research Council (MRC)
NIHR Clinical Research Network: Cancer

Freephone 0808 800 4040

“I was delighted to take part in a clinical trial as it has the potential to really help others in the future.”

A trial looking at chemotherapy after surgery for colorectal cancer (QUASAR 1)

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