Atypical hyperplasia of the breast

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Atypical hyperplasia of the breast

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Ductal breast cancer is thought to begin with abnormal tissue growth in a breast duct. A. Normal breast duct is shown. B. An overgrowth of normal cells may develop in the breast duct (hyperplasia). C. Over time, the cells develop abnormalitities and continue accumulating (atypical hyperplasia). D. The abnormal cells may continue to change in appearance and multiply, evolving into ductal carcinoma in situ. E. Eventually the cancer cells grow beyond the breast duct (invasive ductal carcinoma) and can spread to other areas of the body.

Atypical hyperplasia is a precancerous condition that affects cells in the breast. Atypical hyperplasia describes an accumulation of abnormal cells in the breast.

Atypical hyperplasia isn’t cancer, but it can be a forerunner to the development of breast cancer. Over the course of your lifetime, if the atypical hyperplasia cells keep dividing and become more abnormal, this can transition into noninvasive breast cancer (carcinoma in situ) or invasive breast cancer.

If you’ve been diagnosed with atypical hyperplasia, you have an increased risk of developing breast cancer in the future. For this reason, doctors often recommend intensive breast cancer screening and medications to reduce breast cancer risk.

Atypical hyperplasia usually doesn’t cause any specific symptoms.

Make an appointment with your doctor if you have any signs or symptoms that worry you.

Atypical hyperplasia typically doesn’t cause symptoms, but it may cause changes to appear on a mammogram. Atypical hyperplasia is usually discovered during a breast biopsy to investigate an abnormality found on a mammogram. Sometimes atypical hyperplasia is discovered on a biopsy done for a different condition.

It’s not clear what causes atypical hyperplasia.

Atypical hyperplasia forms when breast cells become abnormal in number, size, shape, growth pattern and appearance. The appearance of the abnormal cells determines the type of atypical hyperplasia:

Atypical hyperplasia is thought to be part of the complex transition of cells that may evolve into breast cancer. The progression to breast cancer typically involves:

If you’ve been diagnosed with atypical hyperplasia, you have an increased risk of developing breast cancer in the future.

Women with atypical hyperplasia have a lifetime risk of breast cancer that is about four times higher than that of women who don’t have atypical hyperplasia. The risk of breast cancer is the same for women with atypical ductal hyperplasia and women with atypical lobular hyperplasia.

Recent research has revealed that the risk of breast cancer increases in the years after an atypical hyperplasia diagnosis:

Being diagnosed with atypical hyperplasia at a younger age may increase the risk of breast cancer even more. For example, women diagnosed with atypical hyperplasia before age 45 seem to have a greater risk of developing breast cancer during their lifetimes.

Discuss your risk of breast cancer with your doctor. Understanding your risk can help you make decisions about breast cancer screening and risk-reducing medications.

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Atypical hyperplasia of the breast

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