Brugada syndrome
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Brugada (brew-GAH-dah) syndrome is a potentially life-threatening heart rhythm disorder that is sometimes inherited. People with Brugada syndrome have an increased risk of abnormal heart rhythms from the lower chambers of the heart (ventricular arrhythmias).
Many people who have Brugada syndrome don’t have any symptoms, and so they’re unaware of their condition. A telltale abnormality — called a type 1 Brugada ECG pattern — is detected by an electrocardiogram (ECG) test. Brugada syndrome is much more common in men than women.
Brugada syndrome is treatable with preventive measures such as avoiding aggravating medications, reducing fever and, when necessary, using a medical device called an implantable cardioverter-defibrillator (ICD).
Many people who have Brugada syndrome are undiagnosed because the condition often doesn’t cause any noticeable symptoms.
The most important sign of Brugada syndrome is an abnormal pattern on an electrocardiogram (ECG) called a type 1 Brugada ECG pattern. You can’t feel a Brugada sign — it’s only detected on an ECG.
It’s possible to have a Brugada sign, or pattern, without having Brugada syndrome. However, signs and symptoms that could mean you have Brugada syndrome include:
Brugada syndrome signs and symptoms are similar to some other heart rhythm problems, so it’s essential that you see your doctor to find out if Brugada syndrome or another heart rhythm problem is causing your symptoms.
If you have heart palpitations or an irregular heartbeat (arrhythmia), make an appointment to see your doctor. Your problem could be caused by a heart rhythm problem, but tests can determine if the underlying cause of your heart problem is Brugada syndrome.
If you faint and you suspect it may be because of a heart condition, seek emergency medical attention.
If your parent, sibling or child has been diagnosed with Brugada syndrome, you may want to make an appointment with your doctor. He or she can discuss whether you should have genetic testing to see if you’re at risk of Brugada syndrome.
Brugada syndrome is a heart rhythm disorder. Each beat of your heart is triggered by an electrical impulse generated by special cells in the right upper chamber of your heart. Tiny pores, called channels, on each of these cells direct this electrical activity, which makes your heart beat.
In Brugada syndrome, a defect in these channels can cause your heart to beat abnormally and spin electrically out of control in an abnormally fast and dangerous rhythm (ventricular fibrillation).
As a result, your heart doesn’t pump effectively and not enough blood travels to the rest of your body. This will cause fainting if that rhythm lasts for only a short time or sudden cardiac death if the heart remains in that bad rhythm.
Brugada syndrome is often inherited, but it may also result from a hard-to-detect structural abnormality in your heart, imbalances in chemicals that help transmit electrical signals through your body (electrolytes), or the effects of certain prescription medications or cocaine use.
Brugada syndrome usually is diagnosed in adults and, sometimes, in adolescents. It’s rarely diagnosed in young children.
Risk factors for Brugada syndrome include:
Complications of Brugada syndrome require emergency medical care. They include:
Sudden cardiac arrest. If not treated immediately, this sudden loss of heart function, breathing and consciousness, which often occurs while sleeping, is fatal. With fast, appropriate medical care, survival is possible.
Administering cardiopulmonary resuscitation (CPR) — rapid compressions to the chest — and an external shock from an automatic external defibrillator (AED) can improve the chances of survival until emergency personnel arrive.
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Brugada syndrome
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