Cancer of unknown primary (CUP)

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Cancer of unknown primary (CUP)

Cancer of unknown primary means that cancer spread has been found in your body (secondary cancer), but your doctors can’t find where the cancer started (the primary cancer). It is sometimes called unknown primary cancer or unknown primary tumour.

The tests and treatments for cancer of unknown primary in children and young adults might be different to adults. The information in this section is for adults with CUP.

Cancer of unknown primary includes a variety of cancers. Find out why we can’t be specific about the possible causes or risk factors of CUP.

Find out what to expect when you see a GP, when you might see a specialist and which tests you may have.

There is no staging system for cancer of unknown primary. This is because the cancer has already spread. Tests might show the type of cell the cancer started in. 

Find out about survival for cancer of unknown primary.

Treatment depends on a number of things, including where the cancer is and your general health. Chemotherapy is the main treatment for CUP.

Advice and support are available to help you cope with cancer of unknown primary and its treatment.

Read about the latest research into cancer of unknown primary and see how you can take part in a clinical trial.

Search our clinical trials database for all cancer trials and studies recruiting in the UK

Talk to other people affected by cancer

Questions about cancer? Call freephone or email us

0808 800 4040

Cancer of unknown primary (CUP)

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