Chronic lymphocytic leukemia

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Chronic lymphocytic leukemia

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Chronic lymphocytic leukemia (CLL) is a type of cancer of the blood and bone marrow — the spongy tissue inside bones where blood cells are made.

The term “chronic” in chronic lymphocytic leukemia comes from the fact that it typically progresses more slowly than other types of leukemia. The term “lymphocytic” in chronic lymphocytic leukemia comes from the cells affected by the disease — a group of white blood cells called lymphocytes, which help your body fight infection.

Chronic lymphocytic leukemia most commonly affects older adults. There are treatments to help control the disease.

Chronic lymphocytic leukemia care at Mayo Clinic

Many people with chronic lymphocytic leukemia have no early symptoms. Those who do develop signs and symptoms may experience:

Make an appointment with your doctor if you have any persistent signs and symptoms that worry you.

Doctors aren’t certain what starts the process that causes chronic lymphocytic leukemia. What’s known is that something happens to cause a genetic mutation in the DNA of blood-producing cells. This mutation causes the blood cells to produce abnormal, ineffective lymphocytes.

Beyond being ineffective, these abnormal lymphocytes continue to live and multiply, when normal lymphocytes would die. The abnormal lymphocytes accumulate in the blood and certain organs, where they cause complications. They may crowd healthy cells out of the bone marrow and interfere with normal blood cell production.

Doctors and researchers are working to understand the exact mechanism that causes chronic lymphocytic leukemia.

Factors that may increase the risk of chronic lymphocytic leukemia include:

Chronic lymphocytic leukemia may cause complications such as:

Chronic lymphocytic leukemia care at Mayo Clinic

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Chronic lymphocytic leukemia

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