Cytosponge: A ‘sponge on a string’ test to detect oesophageal cancer earlier
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The Cytosponge can be used to detect oesophageal cancer earlier.
Around 9,100 people are diagnosed with oesophageal cancer each year in the UK.
A big challenge with this type of cancer is that many people don’t realise there’s a problem until they start to have trouble swallowing. Often, these symptoms aren’t recognisable until a later stage in the disease.
But there may be an opportunity to detect the disease earlier. Some people develop a condition – called Barrett’s oesophagus – prior to developing into cancer.
Barrett’s oesophagus is much more common than oesophageal cancer, and although it will only become cancer in a handful of cases, it presents an opportunity for doctors to spot a problem early and intervene before cancer develops. But the typical test for Barrett’s oesophagus, endoscopy, is both invasive and expensive.
Enter the Cytosponge.
Cytosponge-TFF3 test is a ‘sponge on a string’ device coupled with a laboratory test called TFF3 developed by scientists funded by the Medical Research Council (MRC) and Cancer Research UK – a simple, quick and affordable test for Barrett’s oesophagus that can be done in a GP surgery.
And the latest results, published in The Lancet, suggest this Cytosponge-TFF3 test can identify ten times more people with Barrett’s oesophagus than current GP care.
We caught up with Professor Rebecca Fitzgerald, based at the University of Cambridge, whose team studies oesophageal cancer and has worked hard over the last decade to develop this innovative test.
Cytosponge is a small coated pill on a string that contains the sponge. It’s easy for people to swallow, and when the pill reaches the stomach, the coating dissolves and the sponge expands.
When the sponge is pulled back up, it collects some of the cells lining the oesophagus on its way. The sponge is sent off for analysis in the lab, “where we have developed a simple antibody test called TFF3 so that pathologists can easily spot the signs precancerous condition”.
A seed was planted for the idea for the Cytosponge in around 2000, whilst Fitzgerald was still in London.
“I was talking with my boss, Professor Mike Farthing, about how an endoscopy isn’t ideal for patients and for sampling, and how what you really need is some kind of bottle brush for easy collection of cells.”
But it was when Fitzgerald moved her research to Cambridge in 2002 that she began a prototype for this ‘bottle-brush’ idea. Over the years, the prototype evolved into what’s now recognised as the Cytosponge, which has been tested on thousands of people across the country.
The first real test for Cytosponge was to see if people were willing to try the sponge-on-a-string, and whether the process was feasible in a GP surgery.
And once that hurdle was cleared, it was time to test the accuracy of Cytosponge in clinical trials.
The latest Cytosponge trial compared Cytosponge to the current model for managing people with heartburn symptoms, the main risk factor for Barrett’s and cancer of the oesophagus.
“What GPs ordinarily do if you’ve got reflux symptoms is to give you medication to get rid of the heartburn. So, most patients that see their GP with heartburn won’t get an endoscopy test,” Fitzgerald explains.
“Because the Cytosponge is such a simple test that you can do, basically in 10 minutes in a GP surgery, we wanted to compare what GP’s ordinarily do, with offering all patients who usually receive medication for heartburn the Cytosponge test.”
13,000 patients were enrolled in the study from GP surgeries across England. Half of these patients were offered the standard clinical care, while the other half were offered the Cytosponge.
At the end of the trial, the team analysed how many cases of Barrett’s oesophagus were picked up in each of the two arms of the trial, and the results were quite remarkable.
“We found 10 times more cases of Barrett’s oesophagus in the people that were offered a Cytosponge compared with what GP’s ordinarily do,” says Fitzgerald.
What’s more, the trial picked up a number of early stage cancers too.
“If the cancer is detected early you can cure the disease. You can remove it completely at endoscopy and the patient may not need to have chemotherapy and surgery to remove the oesophagus,” Fitzgerald explains.
The results will not only change the way Barrett’s oesophagus and oesophageal cancer is detected in the future, the success of the BEST3 trial has meant that cancers have been successfully detected and treated in those who took part.
Liz is one of those cases.
Liz took part in the BEST3 trial in 2017.
Liz had suffered with acid reflux for many years. When she received a letter from her GP about the BEST3 trial, she signed up out of pure curiosity.
“I was curious about the trial because I’d never heard of Barrett’s oesophagus and so I just took part out of interest,” Liz explains.
A fortnight after having the Cytosponge test at her local GP surgery, Liz received a letter saying that the test indicated she did have Barrett’s oesophagus. Next, Liz required an endoscopy to clarify the results.
“I went and had an endoscopy and even I could see that things were not very good in my oesophagus. It was extremely inflamed and bleeding and not healthy looking at all.”
The endoscopy also revealed that she had early stage oesophageal cancer, “that was the moment when you suddenly think, oh, this is bad”.
Thankfully, the cancer had been caught early by the Cytosponge. “I didn’t have to have any harmful treatments at all. They could remove it by doing an endoscopic resection,” says Liz.
Liz is a retired scientist, who has experience of working in research labs. “I understood about a lot of the processes,” she explains, “there’s a huge amount of science behind it, but the procedure itself is so simple. It is, to my mind, a perfect test that could easily be carried out widely in the community.”
This was in 2017, at the beginning of the BEST3 trial. Since then, Liz has been busy enjoying life to the full. “Last year, as well as enjoying a 90-mile walk along the Ridgeway, I was able to put my hobby of pottery to good use by making a hundred coasters bearing an image of the Cytosponge. These were sent as a small thank you gift to the research nurses involved in the BEST3 trial.”
The team recently received a grant to begin implementing the Cytosponge test, both in GPs and in secondary care across England in the coming years.
But the onset of the coronavirus pandemic meant that plans were quickly adjusted.
“COVID-19 means that endoscopy services were pretty much shut down,” Fitzgerald explains, “it means that there are people out there who just weren’t being referred, or who had been referred and were being stalled and not getting access to diagnostic tests.”
The team received permission to begin procedures immediately, setting up a ‘COVID Cytosponge clinic’ at the Addenbrooke’s hospital in Cambridge.
“We were taking patients referred by the two week wait from their GP,” says Fitzgerald. “These are people who can still swallow capsules, who don’t sound quite so poorly, but otherwise would have had a delay in getting the endoscopy, who got the Cytosponge test.”
This is a different way of using Cytosponge than had been tested in the previous trials, but analysing the data collected in this Addenbrooke’s pilot will help to find out if Cytosponge can play a useful role in working out who would benefit from an endoscopy the soonest.
The Cytosponge test has reaffirmed the need to continue searching for innovative diagnostic tools, that detect pre-cancerous conditions quickly and non-invasively. One that can help save lives in today’s uncertain circumstances and into the future.
5 October 2020 update: Cytosponge is being introduced in Scotland as a ‘simpler alternative to endoscopy’ in a £500,000 programme. NHS Greater Glasgow and Clyde and NHS Lanarkshire will be the first to implement the test, with training planned for Fife, Borders, Forth Valley and Lothian later this month.
15 December 2020 update: The National Institute for Health and Care Excellence have developed a Medtech innovation briefing on ‘Cytosponge for detecting abnormal cells in the oesophagus’. The briefing aims to support NHS commissioners and staff who are considering implementation of Cytosponge into services. You can read the full briefing, here.
8 July 2021 update: Scotland has announced that the Cytosponge device will now be used across all mainland Scottish health boards in the surveillance of people with Barrett’s Oesophagus. This reflects challenges in securing timely endoscopy for patients but also the interest in exploring the different ways in which Cytosponge could be used to shift patient care and outcomes. We’ll continue to monitor research and evaluation in this area with keen interest.
Lilly
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Fitzgerald RC, et al. (2020). ‘A pragmatic randomised, controlled trial of an offer of Cytosponge-TFF3 test compared with usual care to identify Barrett’s oesophagus in primary care.’ The Lancet. DOI: https://doi.org/10.1016/S0140-6736(20)31099-0
Sally December 22, 2020
I wish this could have been around 20 years ago.my mother died of this horrible Cancer.
The Dr said she was suffering from anxiety! ! As she was choking on her food..? It was a visit to the DENTIST that set alarms off and at last a biopsy..she died 3 months later..
I cried when I read about this simple test that will save many lives.thank God for the team.
Lorna Leaston December 19, 2020
I was so pleased to read about this research, endoscopies can be so unpleasant & this seems such a fantastic innovation in the diagnosis of Barrett’s & in some cases early stage oesophageal cancer. As a survivor of late Stage 3 oesophageal cancer who had to have chemo, radiotherapy & an oesophagectomy, anything that detects it earlier and less invasively is clearly a game changer. CRUK do fantastic things & without the life saving research you do, so many of us would certainly not be here. Thank you!
Gwendoline O’Hehir December 10, 2020
I think what you are doing at cancer research is amazing and I would love to give thousand at this moment in time I can afford to donate £10.00 and hope the year 2021 will be much better.
Thank you all for your hard work and consistent quest to find cures and save lives
M
Harvey Phillips November 30, 2020
I have just been invited to have it as an alternative to regular, unpleasant gastroscopies. Can’t wait!
Dr Ronald Wrighton October 15, 2020
Very interesting to hear of this innovative approach to diagnosis of oesophageal issues.
More please.
Christine Stanbury October 15, 2020
I find this all very interesting. My brother had Barrett’s diagnosed years ago. My Barretts 2cm 2016, 3cm sliding hiatus hernia 2013. Maybe Barrett’s all along. I always thought it a coincidence that both my brother and I had been diagnosed. Neither of us overweight and fit for our ages. Currently I have an endoscopy every three years. My brother had an operation in Kent possibly as early as 2005? Always keen to read any new information and concerned for our sons and their children.
Deanne Goddard October 14, 2020
very interesting; happy to learn what else is on the cutting edge
June Mcdonald September 15, 2020
There are so many different types of cancer, it must be a nightmare trying to concentrate on just a few. But cancer research are there at the forefront, thank you!
William September 15, 2020
So nice to hear positives, in the very present concerning period, is this method being considered for Colon and other cancers? such a simple very clever idea.
Veronica September 15, 2020
Wished this was done for my loved one. Was not even referred by GP although complained of Hoarseness in his voice on and off etc. He took himself to the hospital and got diagnosed
Susan September 14, 2020
This sounds great, my mother died of this cancer and her doctor didn’t take things seriously until she couldn’t swallow food( she had been going to the surgery for months complaining of heartburn) if this had been around in 2005 she may not have died.
Deborah Noonan August 30, 2020
I think the research scientists involved in this work and all work related to finding a cure for cancers are amazing: I think Cancer Research UK do a fantastic job despite not receiving Government funding. It makes you proud to be British.
Mike August 20, 2020
Having endured a number of endoscopies over the years (I was diagoned with Barrett’s oesophagus a number of years ago), I find this is an amazing innovation for detecting oesophagal cancer.. Because it is non-invasive and easy to carry out more people will feel confortable having this procedure done to an endoscopy which can carry a minor risk. I congratulate the research scientists who developed this technique.
Glenys August 20, 2020
That is fantastic progress in detecting oesophagal cancer
Patricia Deakin August 19, 2020
Amazing. Certainly made
me more aware.
George Hudson August 19, 2020
Brilliant progress
So user friendly
alan bunker August 17, 2020
marvellous.my son aged 22, died from this cancer after 4 months treatment.I was sitting by him in hospital when he passed away.however he had the type of cancer called Signet ring.is there a cure for this? Keep up your good work.THANKYOU
Katie Roberts August 18, 2020
Hi Alan,
I’m really sorry to hear about what happened to your son. If you have any questions or want to talk things through it might be helpful to talk to one of our nurses on our helpline. The number is freephone 0808 800 4040 and the lines are open from 9am till 5pm Monday to Friday.
Best wishes,
Katie, Cancer Research UK
Annette August 17, 2020
Brilliant news, can you tell me please will this also be available in Scotland?
Gary Bickerton August 17, 2020
This sounds like a really positive step forward. I was diagnosed with oesophageal cancer ,which had spread to my stomach , last September and endured months of chemo and major surgery , which was thankfully successful , so if this test can help people avoid that horrendous process then I am very pleased.
Joanne Tucker August 17, 2020
I agree with all the responses below, this needs to be out there for all asap
Barbara Reardon August 17, 2020
I think this is brilliant my mother died of oesophageal cancer 10 years ago and I suffer from acid reflux and have done for many years, hope it soon becomes standard practice.
Skye van Heyzen August 17, 2020
What a brilliant development. After suffering from reflux for years I got subjected to a few endoscopies of which some were actually quite traumatic with the anaesthetic not working. Subsequently was diagnosed with minor Barrett’s and a lazy bottom oesophagus, with the delightful news of endoscopy screening required every 5 years. I only hope that this becomes common practice and that I can get screened using this method sooner rather than later,
Penny Scott-Beaulieu August 17, 2020
Wonderful news. This is why I give to Cancer Research. Just hope that GPs use this tool as standard. ( I spent several years being treated for acid reflux before finally being diagnosed with oesophageal cancer and undergoing surgery and chemotherapy- but thanks to our wonderful nhs am still here 20 years later.)
Marcia Panton August 16, 2020
Fantastic willing this can be used throughout the uk health service.
Keep up the good work
Grace Needham August 16, 2020
I would be interesting in knowIng if the “sponge on a string’ will be used for used for Barrett’s surveillance patients instead of the 3 yearly endoscopes.
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Cytosponge: A ‘sponge on a string’ test to detect oesophageal cancer earlier
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