Discovering the p53 cancer protein

by | Feb 15, 2019 | Uncategorized | 0 comments

All Premium Themes And WEBSITE Utilities Tools You Ever Need! Greatest 100% Free Bonuses With Any Purchase.

Greatest CYBER MONDAY SALES with Bonuses are offered to following date: Get Started For Free!
Purchase Any Product Today! Premium Bonuses More Than $10,997 Will Be Emailed To You To Keep Even Just For Trying It Out.
Click Here To See Greatest Bonuses

and Try Out Any Today!

Here’s the deal.. if you buy any product(s) Linked from this sitewww.Knowledge-Easy.com including Clickbank products, as long as not Google’s product ads, I am gonna Send ALL to you absolutely FREE!. That’s right, you WILL OWN ALL THE PRODUCTS, for Now, just follow these instructions:

1. Order the product(s) you want by click here and select the Top Product, Top Skill you like on this site ..

2. Automatically send you bonuses or simply send me your receipt to consultingadvantages@yahoo.com Or just Enter name and your email in the form at the Bonus Details.

3. I will validate your purchases. AND Send Themes, ALL 50 Greatests Plus The Ultimate Marketing Weapon & “WEBMASTER’S SURVIVAL KIT” to you include ALL Others are YOURS to keep even you return your purchase. No Questions Asked! High Classic Guaranteed for you! Download All Items At One Place.

That’s it !

*Also Unconditionally, NO RISK WHAT SO EVER with Any Product you buy this website,

60 Days Money Back Guarantee,

IF NOT HAPPY FOR ANY REASON, FUL REFUND, No Questions Asked!

Download Instantly in Hands Top Rated today!

Remember, you really have nothing to lose if the item you purchased is not right for you! Keep All The Bonuses.

Super Premium Bonuses Are Limited Time Only!

00

Day(s)

:

00

Hour(s)

:

00

Minute(s)

:

00

Second(s)

Get Paid To Use Facebook, Twitter and YouTube
Online Social Media Jobs Pay $25 - $50/Hour.
No Experience Required. Work At Home, $316/day!
View 1000s of companies hiring writers now!

Order Now!

MOST POPULAR

*****
Customer Support Chat Job: $25/hr
Chat On Twitter Job - $25/hr
Get Paid to chat with customers on
a business’s Twitter account.

Try Free Now!

Get Paid To Review Apps On Phone
Want to get paid $810 per week online?
Get Paid To Review Perfect Apps Weekly.

Order Now
!
Look For REAL Online Job?
Get Paid To Write Articles $200/day
View 1000s of companies hiring writers now!

Try-Out Free Now!

How To Develop Your Skill For Great Success And Happiness Including Become CPA? | Additional special tips From Admin

Competency Improvement is certainly the number 1 imperative and important point of achieving authentic good results in most vocations as most people came across in our society together with in Global. For that reason fortuitous to explore together with everyone in the soon after in relation to whatever effective Skill Expansion is; the simplest way or what means we operate to enjoy ambitions and sooner or later one should succeed with what those prefers to conduct each individual time of day meant for a total everyday life. Is it so awesome if you are capable to build up efficiently and discover success in precisely what you dreamed, focused for, follower of rules and did wonders very hard all afternoon and surely you develop into a CPA, Attorney, an person of a massive manufacturer or even a medical doctor who will seriously chip in awesome aid and principles to many others, who many, any contemporary society and city unquestionably adored and respected. I can's imagine I can guide others to be very best skilled level exactly who will chip in major products and elimination valuations to society and communities right now. How delighted are you if you grow to be one like so with your personal name on the headline? I get arrived on the scene at SUCCESS and triumph over all the really hard elements which is passing the CPA examinations to be CPA. Besides, we will also go over what are the dangers, or several other situations that can be on the strategy and the best way I have personally experienced all of them and should indicate you the way to beat them. | From Admin and Read More at Cont'.

Discovering the p53 cancer protein

About cancer

Cancer types

Cancers in general

Causes of cancer

Coping with cancer

Health Professionals

Get involved

Donate

Find an event

Volunteer

Do your own fundraising

More…

Our research

By cancer type

By cancer topic

Near you

By Researcher

More…

Funding for researchers

Research opportunities

Our funding schemes

Applying for funding

How we deliver research

More…

Shop

Find a shop

Shop online

Our eBay store

About us

What we do

Our organisation

Current jobs

Cancer news

More…

ABOUT CANCER

GET INVOLVED

NEWS & RESOURCES

FUNDING & RESEARCH

ABOUT US

Category: Science blog October 4, 2009 Kat ArneyComments are closed

Since its discovery by Professor Sir David Lane – Cancer Research UK’s chief scientist – in the 1970s, a small molecule called p53 has revolutionised our understanding of how cells, including cancer cells, grow and divide. p53 was the first natural ‘tumour suppressor’ found within our cells – something that usually acts to protect us from cancer. We now know that p53 is faulty or inactivated in the majority of human cancers and a wide range of different functions have been ascribed to it.

As part of Our Milestones series, we’ll look at how p53 was discovered, and the impact this has had on cancer research.

To start off, here’s a short video of Professor Lane talking about his research and its importance.

In 1979 Professor Sir David Lane was simply Dr Lane, working with Lionel Crawford at the Imperial Cancer Research Fund (now Cancer Research UK).

Over the preceding few years, modern cancer biology as we know it had begun to emerge. Researchers were starting to understand more about the faulty genes and molecules involved in cancer cells.

Against this backdrop, many scientists – including Lane and Crawford – were investigating a monkey virus called simian virus 40, or SV40, which was known to cause cancer in mouse cells. The virus ‘immortalised’ cells grown in the lab, giving them many of the properties of cancer cells.

Researchers had suspected for a while that two proteins made by the virus – known as the “large T” and “small t” antigens – interacted with as yet unidentified mouse proteins to trigger cancerous changes. Identifying these proteins was thought to be the key to understanding how cancers developed.

In a molecular ‘fishing expedition’, Lane and Crawford set out to look for molecules that stuck to the viral proteins. Their efforts were rewarded. They found one, publishing their findings in the journal Nature – the 1979 paper seems almost ridiculously brief, compared to the bulky tomes of today.

The scientists began by developing an antibody that recognised the SV40 large T antigen. This allowed them to pluck out large-T molecules – and anything stuck to them – from a jumbled up protein mixture taken from mouse cells that had been infected with the SV40 virus.

When they analysed what was stuck to the large T protein using a technique called gel electrophoresis – which sorts proteins by size – they saw that the T antigen seemed much heavier than expected.

Something was indeed sticking to it. There also seemed to be another, smaller protein present – although they needed to work out if it was actually a new protein, or just a smaller fragment of a known viral protein.

Further experiments showed that this was indeed a new protein, with a molecular weight of 53,000 Daltons (53 kiloDaltons). Hence the name p53 – ‘protein of 53kiloDaltons’.

Since there was simply not enough genetic ‘room’ in the SV40 virus’s DNA to make an additional protein, the only conclusion that Lane and Crawford could draw was that the protein was originating from the mouse cells.

The paper predicts that:

“It is possible that [the mystery protein] … may normally act as a regulator of certain cellular functions related to growth control…It is of prime importance to determine the level of this … protein in [normal] cells and to see if it is induced by other carcinogenic agents. ”

On the other side of the Atlantic, while Lane and Crawford were carrying out their experiments, researchers Arnold Levine at Princeton University and Lloyd Old at Sloane-Kettering Memorial Hospital were also coming to the same conclusion via a different route.

Twenty years later, researchers are only just getting to grips with the complex role that p53 plays within the cell, how it is involved in cancer, and whether they can use this knowledge to design new treatments for the disease.

A recent review by Professor Carol Prives and Cancer Research UK’s Professor Karen Vousden highlights how far we have come – and how far we still have to go – in understanding this complicated molecule.

The human gene that encodes p53, TP53, was uncovered in 1984. We now know that one of p53’s key jobs is to act as a ‘transcription factor’, responsible for turning genes on in response to DNA damage.

This has earned p53 the nickname “the guardian of the genome”. It helps to protect us from cancer by causing cells to stop growing – or even die – in response to damage.

You can see it at work if you’ve ever been sunburnt – the resulting peeling skin is the result of p53 switching on a cell ‘suicide’ pathway inside damaged cells, helping to protect us from skin cancer (at least most of the time).

But p53 may perform other jobs too. Since its discovery, it’s been proposed to be involved in cell death, cell ‘sleep’ (senescence), ageing, metabolism, immunity, embryo implantation, cell ‘eating’ (autophagy), DNA repair, growth of new blood vessels (angiogenesis) and cellular stress. It probably makes the tea and does the washing-up as well!

On top of this, and highlighting its ubiquitous role in ‘normal’ cell function, researchers now know that p53 is faulty or switched off in many human cancers. But despite this, attempts to reactivate it in cancer cells haven’t been altogether successful so far. Scientists, including Professor Lane, are still studying p53 and related proteins, looking for ways to reactivate the death pathway in cancer cells.

It’s a highly active research field – for example, we’ve blogged about advances in p53 research, and press-released the discovery of chemicals called Tenovins that can bypass faulty p53 and ‘flick the switch’ on the death pathway.

Just as interesting is research that directly uses the lack of p53 in cancer cells to our advantage. Scientists are now working on viruses and other treatments that only reproduce within and kill cancer cells, because they contain faulty or inactive p53. Healthy cells, with working p53, should be left untouched.

For example, early clinical trials have been carried out using a virus – called Onyx15 – in head and neck cancer, with promising results. Although this work is still at quite an early stage, it holds potential for the future.

This year marks the 30th anniversary of the discovery of p53 – a discovery that changed our understanding of cancer biology, and that Cancer Research UK is proud to have been part of. Over the coming years, we hope to understand more about this enigmatic molecule, and use our knowledge to move forward in beating cancer.

Kat

References:
Vousden, K., & Prives, C. (2009). Blinded by the Light: The Growing Complexity of p53 Cell, 137 (3), 413-431 DOI: 10.1016/j.cell.2009.04.037

Lane, DP & Crawford, LV. (1979). T antigen is bound to a host protein in SV40-transformed cells. Nature, 278 (5701), 261-3

Click here to cancel reply.

Kat Arney
July 14, 2010

Hi Ali,
I’m sorry but we can’t give medical advice on the blog. Please contact our team of specialist Cancer Information Nurses for info about treatment:
http://cancerhelp.org.uk/utilities/contact-us/index.htm

There’s more information about treatment options for breast cancer on our CancerHelp UK website:
http://cancerhelp.cancerresearchuk.org/type/breast-cancer/treatment/index.htm

Best wishes,
Kat

ali alih
July 13, 2010

the best treatment for breast cancer at stage 2 , they suggest mastectomy but we need second opinion
my wife has the lump in the left beast but what is the
best treatment before and after,
please respond very soon

We cover the latest cancer research, including that funded by the charity. We also highlight other relevant material, debunk myths and media scares, and provide links to other helpful resources.

Read our terms and conditions.

Text from Cancer Research UK Science blog by Cancer Research UK, is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike License.

Discovering the p53 cancer protein

Research & References of Discovering the p53 cancer protein|A&C Accounting And Tax Services
Source

Send your purchase information or ask a question here!

10 + 3 =

Welcome To Knowledge-Easy Management Sound Tips and Thank You Very Much! Have a great day!

From Admin and Read More here. A note for you if you pursue CPA licence, KEEP PRACTICE with the MANY WONDER HELPS I showed you. Make sure to check your works after solving simulations. If a Cashflow statement or your consolidation statement is balanced, you know you pass right after sitting for the exams. I hope my information are great and helpful. Implement them. They worked for me. Hey.... turn gray hair to black also guys. Do not forget HEALTH? Expertise Expansion is usually the number 1 fundamental and principal element of having authentic achievements in just about all careers as most people found in a lot of our society and in Around the world. Which means that happy to talk over with you in the following concerning precisely what good Skill Enhancement is;. the correct way or what approaches we job to enjoy ambitions and at some point one might function with what anybody really loves to achieve just about every single working day with regard to a entire living. Is it so amazing if you are able to develop successfully and locate achievements in just what you believed, focused for, picky and previously worked very hard just about every single day and surely you turned out to be a CPA, Attorney, an master of a substantial manufacturer or perhaps even a health care professional who will very bring about wonderful aid and values to other folks, who many, any contemporary society and society unquestionably adored and respected. I can's believe that I can enable others to be top rated professional level who seem to will make contributions sizeable choices and aid values to society and communities presently. How delighted are you if you turned into one just like so with your private name on the headline? I have arrived on the scene at SUCCESS and prevail over many the really hard segments which is passing the CPA qualifications to be CPA. Moreover, we will also handle what are the risks, or various complications that can be on your technique and precisely how I have professionally experienced all of them and will show you how to cure them.

0 Comments

Submit a Comment

Business Best Sellers

 

Get Paid To Use Facebook, Twitter and YouTube
Online Social Media Jobs Pay $25 - $50/Hour.
No Experience Required. Work At Home, $316/day!
View 1000s of companies hiring writers now!
Order Now!

 

MOST POPULAR

*****

Customer Support Chat Job: $25/hr
Chat On Twitter Job - $25/hr
Get Paid to chat with customers on
a business’s Twitter account.
Try Free Now!

 

Get Paid To Review Apps On Phone
Want to get paid $810 per week online?
Get Paid To Review Perfect Apps Weekly.
Order Now!

Look For REAL Online Job?
Get Paid To Write Articles $200/day
View 1000s of companies hiring writers now!
Try-Out Free Now!

 

 
error: Content is protected !!