Rhinovirus (RV) Infection (Common Cold)
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Rhinoviruses (RVs) chiefly cause upper respiratory tract infections (URTIs), but may also infect the lower respiratory tract. Rhinoviruses are the most common cause of the common cold. Although rhinovirus infections occur year-round, the incidence is highest in the fall and the spring (see the image below).
Manifestations of rhinovirus infection typically appear after an incubation period of 12-72 hours and last 7-11 days, but may persist for longer. Signs and symptoms include the following:
Age-related differences in presentation are as follows:
Physical examination findings
Complications
See Clinical Presentation for more detail.
If findings from a thorough history and physical examination are consistent with a viral etiology and no complications are noted, an aggressive workup is rarely necessary. Common laboratory tests (eg, WBC, CBC, ESR) have little value. Because of the prolonged time to obtain positive culture findings, rhinovirus culture has rarely been found useful in clinical settings. PCR testing of respiratory specimens may be useful in evaluating severely immunocompromised patients.
See Workup for more detail.
Rhinovirus infections are predominantly mild and self-limited; thus, treatment is generally focused on symptomatic relief and prevention of person-to-person spread and complications. The mainstays of therapy are as follows:
Other conventional supportive care for the common cold includes the following:
Pharmacologic treatment
See Treatment and Medication for more detail.
Rhinoviruses (RVs) are members of the Picornaviridae family, which includes the human pathogens enterovirus and hepatovirus (notably, hepatitis A virus). More than 100 different subtypes exist in 3 major groups, categorized according to receptor specificity: intercellular adhesion molecule-1 (ICAM-1), low-density lipoprotein (LDL) receptors, and sialoprotein cell receptors.
Rhinovirus infections are chiefly limited to the upper respiratory tract but may cause otitis media and sinusitis; they may also exacerbate asthma, cystic fibrosis, chronic bronchitis, and serious lower respiratory tract illness in infants, elderly persons, and immunocompromised persons. [1, 2] Although infections occur year-round, the incidence is highest in the fall and the spring. Of persons exposed to the virus, 70-80% have symptomatic disease. Most cases are mild and self-limited.
The common cold is an acute respiratory tract infection (RTI) characterized by mild coryzal symptoms, rhinorrhea, nasal obstruction, and sneezing. Although the list of agents that cause the common cold is large, 66-75% of cases are due to 200 antigenically distinct viruses from 8 different genera. Rhinoviruses are the most common of these (25-80% of cases), followed by coronaviruses (10-20%), influenza viruses (10-15%), and adenoviruses (5%).
Although the incidence of acute RTI cannot be clearly defined, because of seasonal and locational variability, it is estimated to range from 3-6 cases per person per year in the United States. Children younger than 1 year have experienced an average of 6-8 episodes of acute RTI. This figure decreases to 3-4 episodes per year by adulthood.
Rhinovirus possesses various transmission modes and can infect a huge population at any given time. Most commonly, rhinoviruses are transmitted to susceptible individuals through direct contact or via aerosol particles. The primary site of inoculation is the nasal mucosa, though the conjunctiva may be involved to a lesser extent. Rhinovirus attaches to respiratory epithelium and spreads locally. The major human rhinovirus receptor is ICAM-1 (found in high quantities in the posterior nasopharynx). [3, 4] Viral particles are usually transmitted via inoculation into the eye or the nose from contact with the fingers that harbor the rhinovirus, especially since rhinoviruses are capable of surviving on hands for hours. [5]
Highly contagious behavior includes nose blowing, sneezing, and physically transferring infected secretions onto environmental surfaces or paper tissue. Contrary to popular belief, behaviors such as kissing, talking, coughing, or even drooling do not contribute substantially to the spread of disease.
Infection rates approximate 50% within the household and range from 0% to 50% within schools, indicating that transmission requires long-term contact with infected individuals. Brief exposures to others in places such as movie theaters, shopping malls, friends’ houses, or doctors’ offices are associated with a low risk of transmission. Because children produce antibodies to fewer serotypes, those who attend school are the most common reservoirs of rhinovirus infection.
The natural response of the human defense system to injury involves ICAM-1, which aids the binding between endothelial cells and leukocytes. Rhinovirus takes advantage of ICAM-1 by using it as a receptor for attachment. In addition, it uses ICAM-1 for subsequent viral uncoating during cell invasion. Some rhinovirus serotypes also upregulate ICAM-1 expression on human epithelial cells to increase susceptibility to infection.
Few cells are actually infected by rhinovirus, and the infection involves only a small portion of the epithelium. Symptoms develop 1-2 days after viral infection, peaking 2-4 days after inoculation, though reports have described symptoms as early as 2 hours after inoculation with primary symptoms 8-16 hours later. [6] Viremia is uncommon.
A local inflammatory response to rhinovirus in the respiratory tract can lead to nasal discharge, nasal congestion, sneezing, and throat irritation. The nasal epithelium is not damaged. [7, 8] Various polymorphisms in cytokine genes have been shown to impact the severity of rhinovirus infection, suggesting a genetic predisposition. [9] Detectable histopathology causing the associated nasal obstruction, rhinorrhea, and sneezing is lacking, which leads to the hypothesis that the host immune response plays a major role in the pathogenesis.
Infected cells release interleukin (IL)–8, which is a potent chemoattractant for polymorphonuclear (PMN) leukocytes. Concentrations of IL-8 in secretions correlate proportionally with the severity of common cold symptoms. Inflammatory mediators, such as kinins and prostaglandins, may cause vasodilatation, increased vascular permeability, and exocrine gland secretion. These, together with local parasympathetic nerve-ending stimulation, lead to cold symptoms.
Deficient production of interferon beta by asthmatic bronchial epithelial cells has been proposed as a mechanism for increased susceptibility to rhinovirus infections in individuals with asthma.
Viral clearance is associated with the host response and is due in part to the local production of nitric oxide. Rhinovirus is shed in large amounts, with as many as 1 million infectious virions present per milliliter of nasal washings. Viral shedding can occur a few days before cold symptoms are recognized by the patient, peaks on days 2-7 of the illness, and may last as long as 3-4 weeks.
Serotype-specific neutralizing antibodies are found 7-21 days after infection in 80% of patients. Although these antibodies persist for years, providing long-lasting immunity, recovery from illness is more likely related to cell-mediated immunity. Persistent protection from repeat infection by that serotype appears to be partially attributable to immunoglobulin A (IgA) antibodies in nasal secretions, serum immunoglobulin G (IgG), and, possibly, serum immunoglobulin M (IgM).
Clinical studies indicate sinus involvement in common colds. Abnormal computed tomography (CT) findings (eg, opacification, air-fluid levels, and mucosal thickening) are present in adults with common colds that resolve over 1-2 weeks without antibiotic therapy.
Despite what is reported in folklore, no good clinical evidence suggests that colds are acquired by exposure to cold weather, getting wet, or becoming chilled.
Rhinoviruses are small, nonenveloped, positive (sense) stranded RNA viruses of the Picornaviridae family. More than 100 different serotypes have been identified, categorized into 3 major groups on the basis of specificity for particular receptors: ICAM-1, LDL receptors, and sialoprotein cell receptors. Their structure is an icosahedral capsid of 12 pentamers containing the 4 viral proteins. A deep cleft is involved in viral attachment. Attachment to cellular receptors can be blocked by a specific antibody.
Rhinovirus grows efficiently only within a limited temperature range (33-35°C), and it cannot tolerate an acidic environment. Thus, it is rarely found outside the nasopharynx, because of the acidic environment of the stomach and the increased temperature in both the lower respiratory tract and the gastrointestinal (GI) tract.
Transmission of rhinovirus occurs with close exposure to infected respiratory secretions, including hand-to-hand contact, self-inoculation of eyes or nose, and, possibly, large- and small-particle aerosolization. The virus has been cultured from the skin after up to 2 hours and after up to 4 days on inanimate objects in ideal conditions. Donors are typically symptomatic with a cold at the time of transmission, and virus is detected on the hands and nasal mucosa.
One study assessed the transfer of virus to surfaces by 15 adults with rhinovirus infection; each of the 15 stayed overnight in a hotel room, and afterward, 10 commonly touched sites in each room were tested for viral contamination. [10] The investigators determined that rhinovirus could be recovered from 35% of these sites and found that the virus could be transferred back from inanimate objects to fingertips in many cases.
Higher rates of transmission occur in humid, crowded conditions such as are found in nurseries, daycare centers, and schools, especially during cooler months in temperate regions and the rainy season in tropical regions. The likelihood of transmission does not appear to be related to exposure to cold temperatures, fatigue, or sleep deprivation.
Factors that increase the risk and severity of rhinovirus infection include the following:
Common colds are most frequent from September to April in temperate climates. Rhinovirus infections, which are present throughout the year, account for the initial increase in cold incidence during the fall (causing as many as 80% of colds in this period) and for a second incidence peak at the end of spring. Colds that occur from October through March are caused by the successive appearance of numerous viruses (see the image below). Adenovirus infections occur at a constant rate throughout the season.
The incidence of the common cold is highest in preschool- and elementary school–aged children. An average of 3-8 colds per year is observed in this age group, and the incidence is even higher in children who attend daycare and preschool. Because of the numerous viral agents involved and the multiple serotypes that several of these agents (especially rhinovirus) have, it is not unusual for younger children having new colds every month during the winter. Adults and adolescents typically have 2-4 colds per year.
Internationally, rhinovirus is a significant cause of RTI, [12, 13, 14, 15, 16, 17, 18, 19, 20] as well as a minor cause of bronchiolitis. [21] Rhinoviruses have been found in all countries, even in remote areas such as the Kaluhi Islands and the Amazon. In Brazil, rhinoviruses reportedly cause 46% of acute RTIs. A seasonal increase in incidence during the winter months is observed worldwide.
Because antibodies to viral serotypes develop over time, the incidence of rhinovirus infection is highest in infants and young children and falls as children approach adulthood. Young children are more likely to have the frequent, close, personal contact necessary to transmit rhinovirus; they commonly pass the infection to family members after acquiring the virus in nurseries, daycare facilities, and schools. Children may also be more contagious by virtue of having higher virus concentrations in secretions and longer duration of viral shedding.
Some reports indicate a male predominance of infection in children younger than 3 years, which switches to a female predominance in children older than 3 years. In adults, no difference in rates of infection between men and women is apparent.
No differences among different races with respect to susceptibility to rhinovirus infection or disease course have been described. In general, Native Americans and Eskimos are more likely to develop the common cold and appear to have higher rates of complications such as otitis media. These findings may be explained as much by environmental conditions (eg, poverty and overcrowding) as by ethnicity.
The prognosis for rhinovirus infection is excellent. The most common manifestation of rhinovirus infection, the common cold, is mild and self-limited. Complete recovery is usually observed within 7 days for adolescents and adults and within 10-14 days for children. Occasionally, a child’s cough and congestion linger for 2-3 weeks.
Although rarely associated with fatal disease, rhinoviruses are associated with significant morbidity. Acute RTIs, predominantly rhinovirus infections, are estimated to cause 30-50% of time lost from work by adults and 60-80% of time lost from school by children. Severe respiratory disease, including bronchiolitis, asthma exacerbations, and pneumonia , [22, 23] can occur, particularly in infants and young children. [24] Preterm infants are also at high risk for severe rhinovirus infection. [25]
Rhinovirus is a predominant pathogen in lower respiratory tract infections (LRTI) in very low birth weight infants [19] and shares predominance in LRTI among young infants with respiratory syncytial virus (RSV). [26, 27] Rhinoviruses may also be involved in LRTIs in elderly persons, persons with cystic fibrosis, and immunosuppressed patients. The true impact of LRTI is not clear. Recovery of rhinovirus in these patients may be a marker of an underlying disease process or a precursor to a bacterial infection.
A retrospective analysis of a prospective cohort of 728 hospitalized elderly patients with rhinovirus infection in Hong Kong revealed a significantly higher 90-day mortality rate than their counterparts (1218 patients) with influenza infection. The rhinovirus group developed pneumonia complications, required oxygen therapy, and had longer hospital stays. [28]
Because spread of secretions by contact with hands is a major route of transmission, encourage parents and patients to wash their hands frequently. In addition, emphasize other environmental measures to control infections, such as avoiding finger-to-eye and finger-to-nose contact and coughing and sneezing into the crook of the elbow.
Reassure families and patients that frequent colds are common at certain times of the year. Inform parents that 6-12 colds per year can be normal for young children, especially if they attend daycare or preschool. Explain that frequent self-limited colds do not indicate a problem with a child’s immune system and do not warrant antibiotic treatment and that patients with common colds need not be excluded from daycare or preschool settings.
Advise patients to return if fever exceeds 102°F, if significant respiratory distress develops, or if symptoms do not resolve in 10-14 days. Remind patients and families that purulent nasal discharge is commonly observed after the first few days of the infection and does not indicate a bacterial infection or the need for antibiotics.
Busse WW, Gern JE, Dick EC. The role of respiratory viruses in asthma. Ciba Found Symp. 1997. 206:208-13; discussion 213-9. [Medline].
Friedlander SL, Busse WW. The role of rhinovirus in asthma exacerbations. J Allergy Clin Immunol. 2005 Aug. 116(2):267-73. [Medline].
Bella J, Rossmann MG. Review: rhinoviruses and their ICAM receptors. J Struct Biol. 1999 Dec 1. 128(1):69-74. [Medline].
Greve JM, Davis G, Meyer AM, Forte CP, Yost SC, Marlor CW, et al. The major human rhinovirus receptor is ICAM-1. Cell. 1989 Mar 10. 56(5):839-47. [Medline].
Royston L, Tapparel C. Rhinoviruses and Respiratory Enteroviruses: Not as Simple as ABC. Viruses. 2016 Jan 11. 8 (1):[Medline].
Lessler J, Reich NG, Brookmeyer R, Perl TM, Nelson KE, Cummings DA. Incubation periods of acute respiratory viral infections: a systematic review. Lancet Infect Dis. 2009 May. 9(5):291-300. [Medline].
Melchjorsen J, Sørensen LN, Paludan SR. Expression and function of chemokines during viral infections: from molecular mechanisms to in vivo function. J Leukoc Biol. 2003 Sep. 74(3):331-43. [Medline].
Message SD, Johnston SL. Host defense function of the airway epithelium in health and disease: clinical background. J Leukoc Biol. 2004 Jan. 75(1):5-17. [Medline].
Doyle WJ, Casselbrant ML, Li-Korotky HS, Doyle AP, Lo CY, Turner R, et al. The interleukin 6 -174 C/C genotype predicts greater rhinovirus illness. J Infect Dis. 2010 Jan 15. 201(2):199-206. [Medline]. [Full Text].
Jennings LC, Anderson TP, Werno AM, Beynon KA, Murdoch DR. Viral etiology of acute respiratory tract infections in children presenting to hospital: role of polymerase chain reaction and demonstration of multiple infections. Pediatr Infect Dis J. 2004 Nov. 23(11):1003-7. [Medline].
Martin ET, Fairchok MP, Stednick ZJ, Kuypers J, Englund JA. Epidemiology of multiple respiratory viruses in childcare attendees. J Infect Dis. 2013 Mar. 207(6):982-9. [Medline].
Jin Y, Yuan XH, Xie ZP, Gao HC, Song JR, Zhang RF, et al. Prevalence and clinical characterization of a newly identified human rhinovirus C species in children with acute respiratory tract infections. J Clin Microbiol. 2009 Sep. 47(9):2895-900. [Medline]. [Full Text].
Peltola V, Jartti T, Putto-Laurila A, Mertsola J, Vainionpää R, Waris M, et al. Rhinovirus infections in children: a retrospective and prospective hospital-based study. J Med Virol. 2009 Oct. 81(10):1831-8. [Medline].
Yoshida LM, Suzuki M, Yamamoto T, Nguyen HA, Nguyen CD, Nguyen AT, et al. Viral pathogens associated with acute respiratory infections in central vietnamese children. Pediatr Infect Dis J. 2010 Jan. 29(1):75-7. [Medline].
Moore HC, Jacoby P, Taylor A, Harnett G, Bowman J, Riley TV, et al. The interaction between respiratory viruses and pathogenic bacteria in the upper respiratory tract of asymptomatic Aboriginal and non-Aboriginal children. Pediatr Infect Dis J. 2010 Jun. 29(6):540-5. [Medline].
Moreira LP, Kamikawa J, Watanabe AS, Carraro E, Leal E, Arruda E, et al. Frequency of human rhinovirus species in outpatient children with acute respiratory infections at primary care level in Brazil. Pediatr Infect Dis J. 2011 Jul. 30(7):612-4. [Medline].
Mak RK, Tse LY, Lam WY, Wong GW, Chan PK, Leung TF. Clinical spectrum of human rhinovirus infections in hospitalized Hong Kong children. Pediatr Infect Dis J. 2011 Sep. 30(9):749-53. [Medline].
Wishaupt JO, Russcher A, Smeets LC, Versteegh FG, Hartwig NG. Clinical impact of RT-PCR for pediatric acute respiratory infections: a controlled clinical trial. Pediatrics. 2011 Nov. 128(5):e1113-20. [Medline].
Miller EK, Bugna J, Libster R, Shepherd BE, Scalzo PM, Acosta PL, et al. Human rhinoviruses in severe respiratory disease in very low birth weight infants. Pediatrics. 2012 Jan. 129(1):e60-7. [Medline]. [Full Text].
Fry AM, Lu X, Olsen SJ, Chittaganpitch M, Sawatwong P, Chantra S, et al. Human rhinovirus infections in rural Thailand: epidemiological evidence for rhinovirus as both pathogen and bystander. PLoS One. 2011 Mar 29. 6(3):e17780. [Medline]. [Full Text].
Miron D, Srugo I, Kra-Oz Z, Keness Y, Wolf D, Amirav I, et al. Sole pathogen in acute bronchiolitis: is there a role for other organisms apart from respiratory syncytial virus?. Pediatr Infect Dis J. 2010 Jan. 29(1):e7-e10. [Medline].
O’Callaghan-Gordo C, Bassat Q, Morais L, Díez-Padrisa N, Machevo S, Nhampossa T, et al. Etiology and epidemiology of viral pneumonia among hospitalized children in rural Mozambique: a malaria endemic area with high prevalence of human immunodeficiency virus. Pediatr Infect Dis J. 2011 Jan. 30(1):39-44. [Medline].
García-García ML, Calvo C, Pozo F, Villadangos PA, Pérez-Breña P, Casas I. Spectrum of Respiratory Viruses in Children With Community-acquired Pneumonia. Pediatr Infect Dis J. 2012 Aug. 31(8):808-13. [Medline].
Louie JK, Roy-Burman A, Guardia-Labar L, Boston EJ, Kiang D, Padilla T, et al. Rhinovirus associated with severe lower respiratory tract infections in children. Pediatr Infect Dis J. 2009 Apr. 28(4):337-9. [Medline].
van Piggelen RO, van Loon AM, Krediet TG, Verboon-Maciolek MA. Human rhinovirus causes severe infection in preterm infants. Pediatr Infect Dis J. 2010 Apr. 29(4):364-5. [Medline].
Van Leeuwen JC, Goossens LK, Hendrix RM, Van Der Palen J, Lusthusz A, Thio BJ. Equal virulence of rhinovirus and respiratory syncytial virus in infants hospitalized for lower respiratory tract infection. Pediatr Infect Dis J. 2012 Jan. 31(1):84-6. [Medline].
García C, Soriano-Fallas A, Lozano J, Leos N, Gomez AM, Ramilo O, et al. Decreased innate immune cytokine responses correlate with disease severity in children with respiratory syncytial virus and human rhinovirus bronchiolitis. Pediatr Infect Dis J. 2012 Jan. 31(1):86-9. [Medline].
Hung IF, Zhang AJ, To KK, Chan JF, Zhu SH, Zhang R, et al. Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection. Int J Mol Sci. 2017 Jan 26. 18 (2):[Medline].
Pappas DE, Hendley JO, Hayden FG, Winther B. Symptom profile of common colds in school-aged children. Pediatr Infect Dis J. 2008 Jan. 27(1):8-11. [Medline].
Winther B, McCue K, Ashe K, Rubino JR, Hendley JO. Environmental contamination with rhinovirus and transfer to fingers of healthy individuals by daily life activity. J Med Virol. 2007 Oct. 79(10):1606-10. [Medline].
Linsuwanon P, Payungporn S, Samransamruajkit R, Theamboonlers A, Poovorawan Y. Recurrent human rhinovirus infections in infants with refractory wheezing. Emerg Infect Dis. 2009 Jun. 15(6):978-80. [Medline]. [Full Text].
Miller EK, Lu X, Erdman DD, Poehling KA, Zhu Y, Griffin MR, et al. Rhinovirus-associated hospitalizations in young children. J Infect Dis. 2007 Mar 15. 195(6):773-81. [Medline].
Jackson DJ, Gangnon RE, Evans MD, Roberg KA, Anderson EL, Pappas TE, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med. 2008 Oct 1. 178(7):667-72. [Medline]. [Full Text].
Looi K, Troy NM, Garratt LW, Iosifidis T, Bosco A, Buckley AG, et al. Effect of human rhinovirus infection on airway epithelium tight junction protein disassembly and transepithelial permeability. Exp Lung Res. 2016 Oct 11. 1-16. [Medline].
Shariff S, Shelfoon C, Holden NS, Traves SL, Wiehler S, Kooi C, et al. Human Rhinovirus Infection of Epithelial Cells Modulates Airway Smooth Muscle Migration. Am J Respir Cell Mol Biol. 2017 Jun. 56 (6):796-803. [Medline].
Glanville N, Peel TJ, Schröder A, Aniscenko J, Walton RP, Finotto S, et al. Tbet Deficiency Causes T Helper Cell Dependent Airways Eosinophilia and Mucus Hypersecretion in Response to Rhinovirus Infection. PLoS Pathog. 2016 Sep. 12 (9):e1005913. [Medline].
Arden KE, Faux CE, O’Neill NT, McErlean P, Nitsche A, Lambert SB, et al. Molecular characterization and distinguishing features of a novel human rhinovirus (HRV) C, HRVC-QCE, detected in children with fever, cough and wheeze during 2003. J Clin Virol. 2010 Mar. 47(3):219-23. [Medline].
Iwane MK, Prill MM, Lu X, Miller EK, Edwards KM, Hall CB, et al. Human rhinovirus species associated with hospitalizations for acute respiratory illness in young US children. J Infect Dis. 2011 Dec 1. 204(11):1702-10. [Medline].
Calvo C, García-García ML, Blanco C, Pozo F, Flecha IC, Pérez-Breña P. Role of rhinovirus in hospitalized infants with respiratory tract infections in Spain. Pediatr Infect Dis J. 2007 Oct. 26(10):904-8. [Medline].
Jackson DJ. The role of rhinovirus infections in the development of early childhood asthma. Curr Opin Allergy Clin Immunol. 2010 Apr. 10(2):133-8. [Medline]. [Full Text].
Wilkinson TM, Hurst JR, Perera WR, et al. Effect of interactions between lower airway bacterial and rhinoviral infection in exacerbations of COPD. Chest. Feb 2006. 129(2):317-24.
Jackson DJ, Gangnon RE, Evans MD, Roberg KA, Anderson EL, Pappas TE, et al. Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children. Am J Respir Crit Care Med. 2008 Oct 1. 178(7):667-72. [Medline]. [Full Text].
Gern JE. Rhinovirus and the initiation of asthma. Curr Opin Allergy Clin Immunol. 2009 Feb. 9(1):73-8. [Medline]. [Full Text].
Martinez FD. The origins of asthma and chronic obstructive pulmonary disease in early life. Proc Am Thorac Soc. 2009 May 1. 6(3):272-7. [Medline]. [Full Text].
Calvo C, Casas I, García-García ML, Pozo F, Reyes N, Cruz N, et al. Role of rhinovirus C respiratory infections in sick and healthy children in Spain. Pediatr Infect Dis J. 2010 Aug. 29(8):717-20. [Medline].
Rosenthal LA, Avila PC, Heymann PW, Martin RJ, Miller EK, Papadopoulos NG, et al. Viral respiratory tract infections and asthma: the course ahead. J Allergy Clin Immunol. 2010 Jun. 125(6):1212-7. [Medline]. [Full Text].
Olenec JP, Kim WK, Lee WM, Vang F, Pappas TE, Salazar LE, et al. Weekly monitoring of children with asthma for infections and illness during common cold seasons. J Allergy Clin Immunol. 2010 May. 125(5):1001-1006.e1. [Medline]. [Full Text].
Busse WW, Lemanske RF Jr, Gern JE. Role of viral respiratory infections in asthma and asthma exacerbations. Lancet. 2010 Sep 4. 376(9743):826-34. [Medline]. [Full Text].
Miller EK. New human rhinovirus species and their significance in asthma exacerbation and airway remodeling. Immunol Allergy Clin North Am. 2010 Nov. 30(4):541-52, vii. [Medline]. [Full Text].
Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ. 1995 May 13. 310(6989):1225-9. [Medline]. [Full Text].
Gavala ML, Bertics PJ, Gern JE. Rhinoviruses, allergic inflammation, and asthma. Immunol Rev. 2011 Jul. 242(1):69-90. [Medline]. [Full Text].
Guilbert TW, Singh AM, Danov Z, Evans MD, Jackson DJ, Burton R, et al. Decreased lung function after preschool wheezing rhinovirus illnesses in children at risk to develop asthma. J Allergy Clin Immunol. 2011 Sep. 128(3):532-8.e1-10. [Medline]. [Full Text].
Jackson DJ, Lemanske RF Jr. The role of respiratory virus infections in childhood asthma inception. Immunol Allergy Clin North Am. 2010 Nov. 30(4):513-22, vi. [Medline]. [Full Text].
Jartti T, Korppi M. Rhinovirus-induced bronchiolitis and asthma development. Pediatr Allergy Immunol. 2011 Jun. 22(4):350-5. [Medline].
Miller EK, Williams JV, Gebretsadik T, Carroll KN, Dupont WD, Mohamed YA, et al. Host and viral factors associated with severity of human rhinovirus-associated infant respiratory tract illness. J Allergy Clin Immunol. 2011 Apr. 127(4):883-91. [Medline]. [Full Text].
Ozcan C, Toyran M, Civelek E, Erkoçoglu M, Altas AB, Albayrak N, et al. Evaluation of respiratory viral pathogens in acute asthma exacerbations during childhood. J Asthma. 2011 Nov. 48(9):888-93. [Medline].
Smuts HE, Workman LJ, Zar HJ. Human rhinovirus infection in young African children with acute wheezing. BMC Infect Dis. 2011 Mar 15. 11:65. [Medline]. [Full Text].
Peltola V, Heikkinen T, Ruuskanen O, Jartti T, Hovi T, Kilpi T, et al. Temporal association between rhinovirus circulation in the community and invasive pneumococcal disease in children. Pediatr Infect Dis J. 2011 Jun. 30(6):456-61. [Medline].
Koponen P, Karjalainen MK, Korppi M. IL10 polymorphisms, rhinovirus-induced bronchiolitis, and childhood asthma. J Allergy Clin Immunol. 2013 Jan. 131(1):249-50. [Medline].
Maggini S, Beveridge S, Suter M. A combination of high-dose vitamin C plus zinc for the common cold. J Int Med Res. 2012. 40(1):28-42. [Medline].
Ruuskanen O, Lahti E, Jennings LC, Murdoch DR. Viral pneumonia. Lancet. 2011 Apr 9. 377(9773):1264-75. [Medline].
Laham FR, Trott AA, Bennett BL, Kozinetz CA, Jewell AM, Garofalo RP, et al. LDH concentration in nasal-wash fluid as a biochemical predictor of bronchiolitis severity. Pediatrics. 2010 Feb. 125(2):e225-33. [Medline]. [Full Text].
Reid AB, Anderson TL, Cooley L, Williamson J, Mcgregor AR. An outbreak of human rhinovirus species C infections in a neonatal intensive care unit. Pediatr Infect Dis J. 2011 Dec. 30(12):1096-5. [Medline].
Liu Y, Hill MG, Klose T, Chen Z, Watters K, Bochkov YA, et al. Atomic structure of a rhinovirus C, a virus species linked to severe childhood asthma. Proc Natl Acad Sci U S A. 2016 Aug 9. 113 (32):8997-9002. [Medline].
Anderson P. High Stroke Risk Transient After Infection in Kids. Medscape Medical News. Available at http://www.medscape.com/viewarticle/830210. Accessed: August 23, 2014.
Hills NK, Sidney S, Fullerton HJ. Timing and number of minor infections as risk factors for childhood arterial ischemic stroke. Neurology. 2014 Aug 20. [Medline].
Gambarino S, Costa C, Elia M, Sidoti F, Mantovani S, Gruosso V, et al. Development of a RT real-time PCR for the detection and quantification of human rhinoviruses. Mol Biotechnol. 2009 Jul. 42(3):350-7. [Medline].
Rogers BB, Shankar P, Jerris RC, Kotzbauer D, Anderson EJ, Watson JR, et al. Impact of a rapid respiratory panel test on patient outcomes. Arch Pathol Lab Med. 2015 May. 139 (5):636-41. [Medline].
Chen EC, Miller SA, DeRisi JL, Chiu CY. Using a pan-viral microarray assay (Virochip) to screen clinical samples for viral pathogens. J Vis Exp. 2011 Apr 27. [Medline]. [Full Text].
Buecher C, Mardy S, Wang W, Duong V, Vong S, Naughtin M, et al. Use of a multiplex PCR/RT-PCR approach to assess the viral causes of influenza-like illnesses in Cambodia during three consecutive dry seasons. J Med Virol. 2010 Oct. 82(10):1762-72. [Medline].
Do DH, Laus S, Leber A, Marcon MJ, Jordan JA, Martin JM, et al. A one-step, real-time PCR assay for rapid detection of rhinovirus. J Mol Diagn. 2010 Jan. 12(1):102-8. [Medline]. [Full Text].
Gambarino S, Costa C, Elia M, Sidoti F, Mantovani S, Gruosso V, et al. Development of a RT real-time PCR for the detection and quantification of human rhinoviruses. Mol Biotechnol. 2009 Jul. 42(3):350-7. [Medline].
Faux CE, Arden KE, Lambert SB, Nissen MD, Nolan TM, Chang AB, et al. Usefulness of published PCR primers in detecting human rhinovirus infection. Emerg Infect Dis. 2011 Feb. 17(2):296-8. [Medline]. [Full Text].
Singh M. Heated, humidified air for the common cold. Cochrane Database Syst Rev. 2004. CD001728. [Medline].
Shehab N, Schaefer MK, Kegler SR, Budnitz DS. Adverse events from cough and cold medications after a market withdrawal of products labeled for infants. Pediatrics. 2010 Dec. 126(6):1100-7. [Medline].
Hayden FG, Herrington DT, Coats TL, Kim K, Cooper EC, Villano SA, et al. Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: results of 2 double-blind, randomized, placebo-controlled trials. Clin Infect Dis. 2003 Jun 15. 36(12):1523-32. [Medline].
Singh M, Singh M. Heated, humidified air for the common cold. Cochrane Database Syst Rev. 2013 Jun 4. CD001728. [Medline].
Paul IM, Beiler JS, King TS, Clapp ER, Vallati J, Berlin CM Jr. Vapor rub, petrolatum, and no treatment for children with nocturnal cough and cold symptoms. Pediatrics. 2010 Dec. 126(6):1092-9. [Medline].
Infant deaths associated with cough and cold medications–two states, 2005. MMWR Morb Mortal Wkly Rep. 2007 Jan 12. 56(1):1-4. [Medline].
Calvo C, Garcia ML, Pozo F, Reyes N, Pérez-Breña P, Casas I. Role of rhinovirus C in apparently life-threatening events in infants, Spain. Emerg Infect Dis. 2009 Sep. 15(9):1506-8. [Medline]. [Full Text].
De Sutter AI, Saraswat A, van Driel ML. Antihistamines for the common cold. Cochrane Database Syst Rev. 2015 Nov 29. CD009345. [Medline].
Science M, Johnstone J, Roth DE, Guyatt G, Loeb M. Zinc for the treatment of the common cold: a systematic review and meta-analysis of randomized controlled trials. CMAJ. 2012 Jul 10. 184 (10):E551-61. [Medline].
Eby GA. Therapeutic Effectiveness of Ionic Zinc for Common Colds. Clinical Infectious Diseases. 01 February 2008. 46(3):483-384.
Caruso TJ, Prober CG, Gwaltney JM Jr. Treatment of naturally acquired common colds with zinc: a structured review. Clin Infect Dis. 2007 Sep 1. 45 (5):569-74. [Medline].
Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev. 2011 Feb 16. CD001364. [Medline].
Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev. 2013 Jun 18. CD001364. [Medline].
Ronald B. Turner. 57. The Common Cold. Edited by John E. Bennett, MD, Raphael Dolin, MD and Martin J. Blaser, MD. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 8th edition. Philadelphia: Saunders, an imprint of Elsevier Inc.; 2015. 748-752.
Saper RB, Rash R. Zinc: an essential micronutrient. Am Fam Physician. 2009 May 1. 79 (9):768-72. [Medline].
Gwaltney JM Jr, Winther B, Patrie JT, Hendley JO. Combined antiviral-antimediator treatment for the common cold. J Infect Dis. 2002 Jul 15. 186(2):147-54. [Medline].
Hayward G, Thompson MJ, Perera R, Del Mar CB, Glasziou PP, Heneghan CJ. Corticosteroids for the common cold. Cochrane Database Syst Rev. 2015 Oct 13. CD008116. [Medline].
Jartti T, Lehtinen P, Vanto T, Hartiala J, Vuorinen T, Mäkelä MJ, et al. Evaluation of the efficacy of prednisolone in early wheezing induced by rhinovirus or respiratory syncytial virus. Pediatr Infect Dis J. 2006 Jun. 25(6):482-8. [Medline].
Turner RB, Wecker MT, Pohl G, Witek TJ, McNally E, St George R, et al. Efficacy of tremacamra, a soluble intercellular adhesion molecule 1, for experimental rhinovirus infection: a randomized clinical trial. JAMA. 1999 May 19. 281(19):1797-804. [Medline].
Akoto C, Davies DE, Swindle EJ. Mast cells are permissive for rhinovirus replication: potential implications for asthma exacerbations. Clin Exp Allergy. 2017 Mar. 47 (3):351-360. [Medline].
Han M, Hong JY, Jaipalli S, Rajput C, Lei J, Hinde JL, et al. IFN-γ Blocks Development of an Asthma Phenotype in Rhinovirus-Infected Baby Mice by Inhibiting Type 2 Innate Lymphoid Cells. Am J Respir Cell Mol Biol. 2017 Feb. 56 (2):242-251. [Medline].
Hayden FG, Turner RB, Gwaltney JM, Chi-Burris K, Gersten M, Hsyu P, et al. Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers. Antimicrob Agents Chemother. 2003 Dec. 47(12):3907-16. [Medline]. [Full Text].
Gern JE, Mosser AG, Swenson CA, Rennie PJ, England RJ, Shaffer J, et al. Inhibition of rhinovirus replication in vitro and in vivo by acid-buffered saline. J Infect Dis. 2007 Apr 15. 195(8):1137-43. [Medline].
Schwartz AR, Togo Y, Hornick RB, Tominaga S, Gleckman RA. Evaluation of the efficacy of ascorbic acid in prophylaxis of induced rhinovirus 44 infection in man. J Infect Dis. 1973 Oct. 128(4):500-5. [Medline].
Guedán A, Swieboda D, Charles M, Toussaint M, Johnston SL, Asfor A, et al. Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication. J Virol. 2017 May 1. 91 (9):[Medline].
Berman R, Jiang D, Wu Q, Chu HW. α1-Antitrypsin reduces rhinovirus infection in primary human airway epithelial cells exposed to cigarette smoke. Int J Chron Obstruct Pulmon Dis. 2016. 11:1279-86. [Medline].
Lee JJ, Shim A, Jeong JY, Lee SY, Ko HJ, Cho HJ. Development of intranasal nanovehicles of itraconazole and their immunological activities for the therapy of rhinovirus infection. Colloids Surf B Biointerfaces. 2016 Jul 1. 143:336-41. [Medline].
Shim A, Song JH, Kwon BE, Lee JJ, Ahn JH, Kim YJ, et al. Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model. Sci Rep. 2016 Mar 15. 6:23110. [Medline].
Stokes CA, Kaur R, Edwards MR, Mondhe M, Robinson D, Prestwich EC, et al. Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes. Mucosal Immunol. 2016 Sep. 9 (5):1303-16. [Medline].
Cagno V, Civra A, Kumar R, Pradhan S, Donalisio M, Sinha BN, et al. Ficus religiosa L. bark extracts inhibit human rhinovirus and respiratory syncytial virus infection in vitro. J Ethnopharmacol. 2015 Dec 24. 176:252-7. [Medline].
Sperber SJ, Shah LP, Gilbert RD, Ritchey TW, Monto AS. Echinacea purpurea for prevention of experimental rhinovirus colds. Clin Infect Dis. 2004 May 15. 38(10):1367-71. [Medline].
Hemilä H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev. 2013 Jan 31. CD000980. [Medline].
Turner RB, Bauer R, Woelkart K, Hulsey TC, Gangemi JD. An evaluation of Echinacea angustifolia in experimental rhinovirus infections. N Engl J Med. 2005 Jul 28. 353(4):341-8. [Medline].
Schoop R, Klein P, Suter A, Johnston SL. Echinacea in the prevention of induced rhinovirus colds: a meta-analysis. Clin Ther. 2006 Feb. 28(2):174-83. [Medline].
Barrett B, Brown R, Rakel D, Mundt M, Bone K, Barlow S, et al. Echinacea for treating the common cold: a randomized trial. Ann Intern Med. 2010 Dec 21. 153(12):769-77. [Medline]. [Full Text].
Turner RB, Biedermann KA, Morgan JM, Keswick B, Ertel KD, Barker MF. Efficacy of organic acids in hand cleansers for prevention of rhinovirus infections. Antimicrob Agents Chemother. 2004 Jul. 48(7):2595-8. [Medline]. [Full Text].
Halperin SA, Eggleston PA, Beasley P, Suratt P, Hendley JO, Gröschel DH, et al. Exacerbations of asthma in adults during experimental rhinovirus infection. Am Rev Respir Dis. 1985 Nov. 132(5):976-80. [Medline].
Singh M, Das RR. Zinc for the common cold. Cochrane Database Syst Rev. 2011 Feb 16. CD001364. [Medline].
Costa LF, Queiróz DA, da Silveira HL, Neto MB, de Paula NT, Oliveira TF, et al. Human Rhinovirus and Disease Severity in Children. Pediatrics. 2014 Jan 13. [Medline].
De Sutter AI, van Driel ML, Kumar AA, Lesslar O, Skrt A. Oral antihistamine-decongestant-analgesic combinations for the common cold. Cochrane Database Syst Rev. 2012 Feb 15. 2:CD004976. [Medline].
Fox S. Severe Pediatric Rhinovirus Linked to RSV Coinfections. Available at http://www.medscape.com/viewarticle/819204. Accessed: January 19, 2014.
Linder JE, Kraft DC, Mohamed Y, Lu Z, Heil L, Tollefson S, et al. Human rhinovirus C: Age, season, and lower respiratory illness over the past 3 decades. J Allergy Clin Immunol. 2013 Jan. 131(1):69-77.e1-6. [Medline].
Joseph Adrian L Buensalido, MD Clinical Associate Professor, Section of Infectious Diseases, Department of Medicine, Philippine General Hospital, University of the Philippines Manila College of Medicine; Specialist in Infectious Diseases, Private Practice
Joseph Adrian L Buensalido, MD is a member of the following medical societies: American Society for Microbiology, Infectious Diseases Society of America, Michigan Infectious Disease Society, Philippine College of Physicians, Philippine Medical Association, Philippine Society for Microbiology and Infectious Diseases
Disclosure: Nothing to disclose.
Jose Carlo B Valencia, MD Medical Specialist III, Department of Medicine, Cagayan Valley Medical Center, Philippines
Jose Carlo B Valencia, MD is a member of the following medical societies: Philippine College of Physicians, Philippine Medical Association, Philippine Society for Microbiology and Infectious Diseases
Disclosure: Nothing to disclose.
Mark R Wallace, MD, FACP, FIDSA Clinical Professor of Medicine, Florida State University College of Medicine; Clinical Professor of Medicine, University of Central Florida College of Medicine
Mark R Wallace, MD, FACP, FIDSA is a member of the following medical societies: American College of Physicians, American Medical Association, American Society for Microbiology, Infectious Diseases Society of America, International AIDS Society, Florida Infectious Diseases Society
Disclosure: Nothing to disclose.
Michael Rajnik, MD Associate Professor, Department of Pediatrics, Program Director, Pediatric Infectious Disease Fellowship Program, Uniformed Services University of the Health Sciences
Michael Rajnik, MD is a member of the following medical societies: American Academy of Pediatrics, Infectious Diseases Society of America, Pediatric Infectious Diseases Society, Armed Forces Infectious Diseases Society
Disclosure: Nothing to disclose.
Duane R Hospenthal, MD, PhD Professor of Medicine, Uniformed Services University of the Health Sciences; Physician, Infectious Disease Service, San Antonio Military Medical Center (formerly Brooke Army Medical Center)
Duane R Hospenthal, MD is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Society for Microbiology, American Society of Tropical Medicine and Hygiene, Armed Forces Infectious Diseases Society, Association of Military Surgeons of the US, Infectious Diseases Society of America, International Society for Human and Animal Mycology, International Society for Infectious Diseases, International Society of Travel Medicine, and Medical Mycology Society of the Americas
Disclosure: Nothing to disclose.
James D Korb, MD Program Director, Department of Pediatrics, Children’s Hospital of Orange County
Disclosure: Nothing to disclose.
Larry I Lutwick, MD Professor of Medicine, State University of New York Downstate Medical School; Director, Infectious Diseases, Veterans Affairs New York Harbor Health Care System, Brooklyn Campus
Larry I Lutwick, MD is a member of the following medical societies: American College of Physicians and Infectious Diseases Society of America
Disclosure: Nothing to disclose.
Clinton Murray, MD
Program Director, Infectious Disease Fellowship, San Antonio Uniformed Services Health Education Consortium
Clinton Murray, MD is a member of the following medical societies: American College of Physicians-American Society of Internal Medicine, American Medical Association, American Society for Microbiology, American Society of Tropical Medicine and Hygiene, Association of Military Surgeons of the US, and Infectious Diseases Society of America
Disclosure: Nothing to disclose.
Mai Ngoc Nguyen, MD
Staff Physician, Department of Pediatrics, Mattel Children’s Hospital, University of California at Los Angeles
Mai Ngoc Nguyen, MD is a member of the following medical societies: American Academy of Pediatrics, and American Medical Association
Disclosure: Nothing to disclose.
José Rafael Romero, MD Director of Pediatric Infectious Diseases Fellowship Program, Associate Professor, Department of Pediatrics, Combined Division of Pediatric Infectious Diseases, Creighton University/University of Nebraska Medical Center
José Rafael Romero, MD is a member of the following medical societies: American Academy of Pediatrics, American Society for Microbiology, Infectious Diseases Society of America, New York Academy of Sciences, and Pediatric Infectious Diseases Society
Disclosure: Nothing to disclose.
Gregory William Rutecki MD Professor of Medicine, University of South Alabama Medical School
Gregory William Rutecki is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians, American Society of Nephrology, National Kidney Foundation, and Society of General Internal Medicine
Disclosure: Nothing to disclose.
Russell W Steele, MD Head, Division of Pediatric Infectious Diseases, Ochsner Children’s Health Center; Clinical Professor, Department of Pediatrics, Tulane University School of Medicine
Russell W Steele, MD is a member of the following medical societies: American Academy of Pediatrics, American Association of Immunologists, American Pediatric Society, American Society for Microbiology, Infectious Diseases Society of America, Louisiana State Medical Society, Pediatric Infectious Diseases Society, Society for Pediatric Research, and Southern Medical Association
Disclosure: Nothing to disclose.
Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference
Disclosure: Medscape Salary Employment
Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference
Disclosure: Nothing to disclose.
Gordon L Woods, MD Consulting Staff, Department of Internal Medicine, University Medical Center
Gordon L Woods, MD is a member of the following medical societies: Society of General Internal Medicine
Disclosure: Nothing to disclose.
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