Temporomandibular Disorders
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The normal human skull possesses 2 temporomandibular joints (TMJs) that connect the skull to the lower jaw bone (the mandible) so as to allow the mouth to open and close. The TMJ is a, gliding joint, formed by the condyle of the mandible and the squamous portion of the temporal bone. It is lined by fibrous connective tissue and enclosed within a fibrous capsule extending from the margins of the temporal portion of the joint superiorly to the neck of the mandible inferiorly. The articular surface of the temporal bone consists of a convex articular eminence anteriorly and a concave articular fossa posteriorly. The articular surface of the mandible consists of the top of the condyle. Articular surfaces of the mandible and temporal bone are separated by an articular disk, which divides the joint cavity into 2 small synovial cavities, the superior and inferior compartments. Gliding movements of the mandible (retrusion and protrusion) occur in the superior compartment. Hinge movements of the mandible (elevation and depression) occur in the inferior compartment. The joint is reinforced by multiple ligaments connecting the mandible to the sphenoid and temporal bones, and supported by the muscles of mastication. The joint is also surrounded on both sides by multiple important structures, which can be damaged during medical procedures.
The articular disk, also known as the meniscus, is a biconcave, fibrocartilaginous structure, which provides the gliding surface for the mandibular condyle, resulting in smooth joint movement. The meniscus has 3 parts—a thick anterior band, a thin intermediate zone, and a thick posterior band. With the mouth closed, the condyle is separated from the articular fossa of the temporal bone by the thick posterior band. When the mouth is open, the condyle is separated from the articular eminence of the temporal bone by the thin intermediate zone.
Movement of the TMJ is produced primarily by the muscles of mastication (masseter, medial and lateral pterygoids, and temporalis). All of these muscles arise from the first pharyngeal arch and are innervated by the third branch of the trigeminal nerve, the mandibular nerve. Their main action is to chew food by closing the mouth and moving the teeth from side to side. Parafunctional actions such as clenching and grinding can lead to pathology. Opening of the mouth is chiefly due to gravity, but can be performed against resistance primarily by the actions of the infrahyoid muscles and the platysma.
Temporomandibular disorder(s) (TMD), or temporomandibular joint syndrome, represent an array of pathologies affecting the TMJ and its surrounding structures. These disorders are linked in that they all can cause pain and limit the function of the TMJ. TMD is the most common cause of facial pain after toothache. In the past, many physicians called this condition TMJ disease or TMJ syndrome, but this nomenclature was replaced due to the growing body of scientific research regarding these disorders.TMD was previously known under the eponymous title of Costen syndrome, after Dr. James Costen, who elucidated many aspects of the syndrome as it relates to dental malocclusion. Today, a much more comprehensive view of this condition exists, and the term temporomandibular disorder (TMD) is the preferred term according to the American Academy of Orofacial Pain (AAOP) and most other groups who sponsor studies into its origins and treatment. Interestingly, the National Institute of Dental and Craniofacial Research (NIDCR) puts TMJ and TMD together and refers to them as temporomandibular joint disorder (TMJD). However, the term TMD is preferred and used in this article.
No unequivocal definition of the disease exists and 2 classification schemes are used. The AAOP classification divides TMD broadly into 2 syndromes:
Of note, these 2 types often coexist in one patient, making diagnosis and treatment more challenging. In addition, due to the anatomy of the mandible, dysfunction of one joint can impact the contralateral joint, and bilateral symptoms are common.
Myogenous TMD is more common. In its pure form, it lacks apparent destructive changes of the TMJ on radiograph and can be caused by multiple etiologies such as bruxism and daytime jaw clenching.
Arthrogenous TMD can be further specified as disk displacement disorder, chronic recurrent dislocations, degenerative joint disorders, systemic arthritic conditions, ankylosis, infections, and neoplasia. The most common is displacement disorder, which has two subtypes: anterior displacement with reduction and anterior displacement without reduction.
The Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) also exist. [1] The RDC/TMD criteria are composed of algorithms that aid in obtaining a diagnosis along 2 separate axes. The Axis I score provides what is considered the clinical diagnosis, and the Axis II score provides an assessment of mandibular function, psychological status, and level of TMD-related psychosocial disability. This discussion emphasizes the terminology and viewpoint of the AAOP approach. However, the authors are mindful of the important features of the RDC/TMD system. As is the case for most diseases and syndromes, the effect on the patient’s life is a major feature of the problem and the psychological and psychosocial aspects are of great importance, and consideration of these factors necessitates a multidisciplinary approach in difficult cases.
In myogenous temporomandibular disorder, the most common cause of the symptomatology (ie, pain, tenderness, and spasm of the mastication muscles) is muscular hyperactivity and dysfunction due to either parafunctional activities, or malocclusion of variable degree and duration. Psychological factors may also play a role. Studies have also linked regulatory pain pathways and local spread of pain signals within the cells of the spinal trigeminal nucleus to the severity, chronicity, and location of pain.
In TMD of articular origin, disk displacement is the most common cause. Abnormal anterior displacement and interposition of the posterior band between the condyle and the eminence cause pain, pops, and crepitus. If the anteriorly displaced posterior band spontaneously returns to the normal position before the completion of jaw opening, it is called anterior displacement with reduction. It must be emphasized, however, that the presence of pops and clicks denoting anterior displacement with reduction does not necessarily denote pathology and studies of healthy populations have found these signs in a large percentage of individuals who did not later develop symptoms of TMD.
The sudden reduction of the posterior band causes the characteristic pop or click. If the posterior band remains anteriorly displaced at all times during jaw opening, it is called anterior displacement without reduction; full jaw opening may not be possible, and the distance between the incisors is usually less than 25mm. The jaw will usually deviate to the side of pathology. Inability to attain a jaw opening of more than 10 mm is known as closed lock. In TMD of articular origin, the spasm of the mastication muscle is secondary in nature.
The other causes of arthrogenous TMD are diseases such as degenerative joint disease, rheumatoid arthritis, ankylosis, dislocations, infections, and neoplasia, the pathophysiology of which are self-explanatory. One study found that, in patients with chronic inflammatory connective tissue disease, the pain on mandibular movement and tenderness on posterior palpation of temporomandibular joints was related to the level of tumor necrosis factor alpha in the synovial fluid.
In a separate study, interleukin 1 receptor antagonist (IL-1ra) and soluble IL-1 receptor II (sIL-1RII) in the synovial fluid and blood plasma of patients with TMJ involvement of polyarthritis appeared to influence the TMJ inflammation. [2]
An important development may connect some of the psychosocial aspects of the disease to underlying neurobiology. This is the discovery that the likelihood of a patient being diagnosed with TMD is related to genetic variations in the gene coding for catecholamine-O-methyltransferase (COMT), a gene that relates in to some aspects of pain sensitivity.
United States
Temporomandibular disorder is a commonly seen condition in primary care and dentistry practice. According to some authorities, as many as 75% of the people in the United States population will at some time have some of the signs and symptoms of TMD; however, all of these individuals are not believed to have TMD. Between 5% and 10% of Americans may sufficiently fulfill the criteria to merit a diagnosis of TMD.
In a recent study of young women aged 19-23 years, facial pain and jaw symptoms related to TMD were noted more frequently in Caucasians than in African Americans. Such symptoms also had an earlier onset in Caucasians.
Temporomandibular disorder primarily affects women with a male-to-female ratio of 1:4.
Highest incidence is among young adults, especially women aged 20-40 years.
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Joseph Rios, MD Assistant Professor, Department of Medical Education, University of Central Florida College of Medicine
Joseph Rios, MD is a member of the following medical societies: American Academy of Neurology, American Chemical Society, American College of Physicians, American College of Surgeons, American Medical Association
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Michael J Schneck, MD, MBA Vice Chair and Professor, Departments of Neurology and Neurosurgery, Loyola University, Chicago Stritch School of Medicine; Associate Director, Stroke Program, Director, Neurology Intensive Care Program, Medical Director, Neurosciences ICU, Loyola University Medical Center
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