A trial looking at different doses of aspirin to prevent cancer in people who have Lynch syndrome (CaPP3)

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A trial looking at different doses of aspirin to prevent cancer in people who have Lynch syndrome (CaPP3)

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This trial is comparing 3 different doses of aspirin as a way of stopping cancer developing in people who have Lynch syndrome. 

Cancer Research UK supports this trial.

People who have Lynch syndrome (also known as HNPCC)  have inherited a faulty version of a gene, which increases their chances of developing certain cancers including bowel cancer and womb cancer.

A trial called CAPP2 showed that aspirin reduces the risk of cancer in people with Lynch syndrome. But in a small number of people, aspirin can cause bleeding in the stomach. This happens more often when people take higher doses of aspirin. So researchers want to see if lower doses of aspirin work as well.

The aim of this trial is to find the best dose of aspirin that people with Lynch syndrome should take to prevent cancer.

You may be able to join this trial if all of the following apply. You

You cannot join this trial if any of these apply. You

This is an international phase 3 trial. The researchers need about 2000 people to take part worldwide and hope that around 1500 people from the UK will take part. Everybody joining the trial will take aspirin tablets each day.

This trial is in 2 parts.

Part 1 of trial is randomised. The people taking part are put into 1 of the following treatment groups by a computer:  

Neither you nor your doctor will be able to decide which group you are in.  Also, whatever dose of aspirin you take, the tablets will look the same, so neither you nor your doctor will know which group you are in. This is called a double blind trial.

You take aspirin for 2 years. Then you see the trial doctor and find out which dose of aspirin you have had. This is part 2 of the trial.

In part 2 you continue taking aspirin for 3 more years. You take:

The researchers expect the trial to finish in 2024.  

CAPP3 diagram

The trial team will contact you by phone after 3 months, 6 months, a year and 18 months. They will check how you are getting on and ask some questions about your health. The phone calls should take no longer than 20 minutes. After 2 years of treatment, they will phone you once a year.

You can also contact your research nurse or doctor if you have any problems or questions. 

The trial team will look at your medical records. All the information they collect about you will be kept confidential.

You will see the trial team before you join the trial. If you agree to take part, you have a blood test. You start taking aspirin shortly afterwards. The tablets will be delivered to your home every 6 months.

You see the trial team again after 2 years and 5 years. The researchers will ask you to give more blood samples at these visits.

The most serious side effect of aspirin is bleeding. Other possible side effects include

Very rarely people have an allergic reaction to aspirin. And it can sometimes make asthma worse.

It is important to remember that millions of people around the world take aspirin with very few side effects. The trial team will talk to you about all the possible risks before you agree to join.

Please note: In order to join a trial you will need to discuss it with your doctor, unless otherwise specified.

Professor Sir John Burn

Bayer Pharma AG
Cancer Research UK
NIHR Clinical Research Network: Genetics
Newcastle University
Newcastle upon Tyne Hospitals NHS Foundation Trust

This is Cancer Research UK trial number CRUK/12/039.

There is more information on the CaPP3 website.

Freephone 0808 800 4040

Last year in the UK over 60,000 cancer patients enrolled on clinical trials aimed at improving cancer treatments and making them available to all.

Find out more about our research on clinical trials

A trial looking at different doses of aspirin to prevent cancer in people who have Lynch syndrome (CaPP3)

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A trial looking at different doses of aspirin to prevent cancer in people who have Lynch syndrome (CaPP3)

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