Benign Lymphangioendothelioma
No Results
No Results
processing….
Benign lymphangioendothelioma (BLAE) (also known as acquired progressive lymphangioma) is an uncommon vascular tumor that is of importance primarily because it can be confused histologically with Kaposi sarcoma (KS) or angiosarcoma. [1, 2] Jones et al first described the tumor as acquired progressive lymphangioma and later as benign lymphangioendothelioma. [3]
Benign lymphangioendothelioma is a proliferation of lymphatic endothelial cells that stain positively for CD31, CD34, podoplanin (D2-40, a lymphatic marker), LYVE-1, and PORX-1. [4, 5] Benign lymphangioendothelioma is not associated with preexisting vascular malformations or lymphedema. Although the lesion rarely is identified during infancy, some suggest it is a hamartoma that first becomes apparent during adolescence or young adult life; the development of benign lymphangioendothelioma is possibly triggered by hormonal changes.
In most instances, the cause is unknown. Trauma has often been blamed, [6] but a reliable connection has never been established. A reactive process versus tumoral etiology is suggested in some literature. [7] In one patient, femoral arteriography was proposed to be a trigger. [8] One case has been reported in association with HIV/AIDS. [9]
Benign lymphangioendothelioma is rare; fewer than 30 cases have been reported.
No racial predisposition is reported.
Males and females are affected equally.
Benign lymphangioendothelioma can affect patients ranging from age 17-90 years (median age 54 y). [1]
The prognosis is excellent.
Inform patients they have a rare (though benign) vascular tumor that is poorly understood, and annual screening is recommended.
Guillou L, Fletcher CD. Benign lymphangioendothelioma (acquired progressive lymphangioma): a lesion not to be confused with well-differentiated angiosarcoma and patch stage Kaposi’s sarcoma: clinicopathologic analysis of a series. Am J Surg Pathol. 2000 Aug. 24(8):1047-57. [Medline].
Requena L, Sangueza OP. Cutaneous vascular proliferation. Part II. Hyperplasias and benign neoplasms. J Am Acad Dermatol. 1997 Dec. 37(6):887-919; quiz 920-2. [Medline].
Jones EW, Winkelmann RK, Zachary CB, Reda AM. Benign lymphangioendothelioma. J Am Acad Dermatol. 1990 Aug. 23(2 Pt 1):229-35. [Medline].
Messeguer F, Sanmartín O, Martorell-Calatayud A, Nagore E, Requena C, Guillen-Barona C. [Acquired progressive lymphangioma (benign lymphangioendothelioma)]. Actas Dermosifiliogr. 2010 Nov. 101(9):792-7. [Medline].
Wang L, Chen L, Yang X, Gao T, Wang G. Benign lymphangioendothelioma: a clinical, histopathologic and immunohistochemical analysis of four cases. J Cutan Pathol. 2013 Nov. 40 (11):945-9. [Medline].
Mizuno K, Okamoto H. Benign lymphangioendothelioma on a vascular birthmark following examination of a cardiac catheter. Int J Dermatol. 2015 Jul. 54 (7):e273-4. [Medline].
Fernandez-Flores A. Benign lymphangioendothelioma. Dermatopathonline. Available at http://www.dermatopathonline.com/lymphangioendothelioma2.html. Accessed: February 24, 2013.
Kato H, Kadoya A. Acquired progressive lymphangioma occurring following femoral arteriography. Clin Exp Dermatol. 1996 Mar. 21(2):159-62. [Medline].
Paik AS, Lee PH, O’Grady TC. Acquired progressive lymphangioma in an HIV-positive patient. J Cutan Pathol. 2007 Nov. 34(11):882-5. [Medline].
Schnebelen AM, Page J, Gardner JM, Shalin SC. Benign lymphangioendothelioma presenting as a giant flank mass. J Cutan Pathol. 2015 Mar. 42 (3):217-21. [Medline].
Revelles JM, Díaz JL, Angulo J, Santonja C, Kutzner H, Requena L. Giant benign lymphangioendothelioma. J Cutan Pathol. 2012 Oct. 39 (10):950-6. [Medline].
Hwang LY, Guill CK, Page RN, Hsu S. Acquired progressive lymphangioma. J Am Acad Dermatol. 2003 Nov. 49(5 Suppl):S250-1. [Medline].
Kim HS, Kim JW, Yu DS. Acquired progressive lymphangioma. J Eur Acad Dermatol Venereol. 2007 Mar. 21(3):416-7. [Medline].
Herron GS, Rouse RV, Kosek JC, Smoller BR, Egbert BM. Benign lymphangioendothelioma. J Am Acad Dermatol. 1994 Aug. 31(2 Pt 2):362-8. [Medline].
Watanabe M, Kishiyama K, Ohkawara A. Acquired progressive lymphangioma. J Am Acad Dermatol. 1983 May. 8(5):663-7. [Medline].
Donald Shenenberger, MD, FAAD, FAAFP Board Certified Dermatologist
Donald Shenenberger, MD, FAAD, FAAFP is a member of the following medical societies: American Academy of Dermatology, American Academy of Family Physicians, Association of Military Dermatologists, Medical Society of Virginia, Uniformed Services Academy of Family Physicians
Disclosure: Nothing to disclose.
David F Butler, MD Former Section Chief of Dermatology, Central Texas Veterans Healthcare System; Professor of Dermatology, Texas A&M University College of Medicine; Founding Chair, Department of Dermatology, Scott and White Clinic
David F Butler, MD is a member of the following medical societies: Alpha Omega Alpha, American Academy of Dermatology, American Society for MOHS Surgery, Association of Military Dermatologists, Phi Beta Kappa
Disclosure: Nothing to disclose.
Rosalie Elenitsas, MD Herman Beerman Professor of Dermatology, University of Pennsylvania School of Medicine; Director, Penn Cutaneous Pathology Services, Department of Dermatology, University of Pennsylvania Health System
Rosalie Elenitsas, MD is a member of the following medical societies: American Academy of Dermatology, American Medical Association, American Society of Dermatopathology, Pennsylvania Academy of Dermatology
Disclosure: Received royalty from Lippincott Williams Wilkins for textbook editor.
Dirk M Elston, MD Professor and Chairman, Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina College of Medicine
Dirk M Elston, MD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.
Gregory J Raugi, MD, PhD Professor, Department of Internal Medicine, Division of Dermatology, University of Washington at Seattle School of Medicine; Chief, Dermatology Section, Primary and Specialty Care Service, Veterans Administration Medical Center of Seattle
Gregory J Raugi, MD, PhD is a member of the following medical societies: American Academy of Dermatology
Disclosure: Nothing to disclose.
Walter HC Burgdorf, MD Clinical Lecturer, Department of Dermatology, Ludwig Maximilian University, Munich, Germany
Walter HC Burgdorf, MD is a member of the following medical societies: American Academy of Dermatology, American Dermatological Association, American Society of Dermatopathology, International Society of Dermatopathology, and Society for Pediatric Dermatology
Disclosure: Nothing to disclose.
Benign Lymphangioendothelioma
Research & References of Benign Lymphangioendothelioma|A&C Accounting And Tax Services
Source
0 Comments