Diffuse Large B-Cell Lymphoma (Non-Hodgkin Lymphoma) Treatment Protocols 

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Diffuse Large B-Cell Lymphoma (Non-Hodgkin Lymphoma) Treatment Protocols 

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Treatment recommendations for patients with diffuse large B-cell lymphoma (DLBCL) begin with evaluating the extent of the disease, performance status of the patient, and histologic subtypes. Treatment of localized and advanced disease varies considerably.

Below is a general treatment algorithm for DLBCL, followed by treatment recommendations for different stages of disease and for relapsed or refractory disease. [1, 2, 3]

Diagnosis of DLBCL:

Staging/IPI score/bulky disease

Assess end-organ function

Establish therapy endpoints (ie, cure vs palliation)

Stage I/II (nonbulky) disease:

Rituximab (R) plus cyclophosphamide, vincristine, doxorubicin, and prednisone (CHOP) for 3-4 cycles

Follow with involved field radiation therapy (IFRT)

If positron emission tomography (PET) is positive after 4 cycles, administer 2 more cycles before IFRT

If relapse occurs, see step 4

Advanced-stage (stage III-IV) or bulky stage II disease:

R+CHOP every 21 d for 6 cycles, with or without IFRT for bulky sites

Prophylactic intrathecal (IT) chemotherapy in selected cases or

Clinical trial with correlative science studies (eg, R+CHOP-like and other biological agents or small molecules and/or other novel monoclonal antibodies [mAbs] or immunoconjugates)

In cases of relapse:

Staging/IPI score/bulky disease

Assess end-organ function

In relapse patients, collect lymphoid tissue and store for future analysis or current research evaluating gene profiling, proteomic analysis, biomarkers of disease (MUM-1, Bcl-6, and CD10), and preclinical studies with novel agents

Relapse patients eligible for high-dose chemotherapy (HDC) and autologous stem cell transplantation (ASCT):

Platinum-based salvage chemotherapy, [4] including rituximab, ifosfamide, carboplatin, and etoposide (RICE) for 2-3 cycles or

Rituximab plus cisplatin, cytarabine, and dexamethasone (DHAP) for 2-3 cycles

If partial or complete response is achieved, use HDC and ASCT

Observation or clinical trials evaluating agents in the maintenance setting may be recommended

If patient relapses, consider clinical trials evaluating novel agents (eg, bortezomib, lenalidomide, or immunoconjugates) or

Radioimmunotherapy (RIT)

Relapse patients not eligible for HDC and ASCT:

Palliative chemotherapy (gemcitabine-based therapy

Clinical trials evaluating novel agents (eg, bortezomib, lenalidomide, or immunoconjugates) or

RIT

Stage I and selected stage II:

Patients without adverse risk factors present:

R+CHOP: Combined therapy with rituximab 375 mg/m2 IV on day 1 plus cyclophosphamide 750 mg/m2 IV on day 1 or 3 plus doxorubicin 50 mg/m2 IV on day 1 or 3 plus vincristine 1.4 mg/m2 (maximum dose, 2 mg) IV on day 1 or 3 plus prednisone 40 mg/m2 PO on days 1-5 or 3-8; every 21d for 3 cycles [5]

Radiographic studies including functional imaging (eg, PET scan) to document response to treatment should be done before initiation of IFRT and/or at the end of therapy

Always confirm residual PET abnormalities with biopsy before modifying therapy

Patients with adverse risk factors present:

R+CHOP: Combined therapy with rituximab plus  cyclophosphamide 750 mg/m2 IV on day 1 or 3 plus  doxorubicin 50 mg/m2 IV on day 1 or 3 plus  vincristine 1.4 mg/m2 (maximum dose, 2 mg) IV on day 1 or 3 plus  prednisone 40 mg/m2 PO on days 1-5 or 3-8; every 21d for 3 cycles followed by IFRT [5] or

R+CHOP: Rituximab 375 mg/m2 IV on day 1 plus  cyclophosphamide 750 mg/m2 IV on day 1 or 3 plus  doxorubicin 50 mg/m2 IV on day 1 or 3 plus  vincristine 1.4 mg/m2 (maximum dose, 2 mg) IV on day 1 or 3 plus  prednisone 40 mg/m2 PO on days 1-5 or 3-8; every 21d for 6 cycles with or without IFRT [6]

Radiographic studies including functional imaging (eg, PET scan) to document response to treatment should be done before initiation of IFRT and/or at the end of therapy

Always confirm residual PET abnormalities with biopsy before modifying therapy

Stages III-IV:

R+CHOP: Rituximab 375 mg/m2 IV on day 1 plus  cyclophosphamide 750 mg/m2 IV on day 1 or 3 plus  doxorubicin 50 mg/m2 IV on day 1 or 3 plus  vincristine 1.4 mg/m2 (maximum dose, 2 mg) IV on day 1 or 3 plus  prednisone 40 mg/m2 PO on days 1-5 or 3-8; every 21d for 6 cycles with or without IFRT [6, 7]

Consider radiation therapy to bulky sites of disease at the end of chemoimmunotherapy

Prophylactic IT chemotherapy with low-dose methotrexate (eg, 12 mg) should be routinely administered to DLBCL patients with the following characteristics [8, 9] :

More than one extranodal site of disease

Testicular or breast involvement, regardless of stage

Lymphoblastic variants

Oropharyngeal or paraspinal sites of involvement

Bone marrow involvement

Concomitant infection with HIV

Patients eligible for HDC-ASCT (treatment goal = cure):

A vast number of regimens are used in the treatment of patients with relapsed or refractory DLBCL. These are primarily based on chemotherapy agents that are not cross-resistant to those used in the front-line setting, with or without rituximab. The goal of salvage regimens is to achieve maximum tumor burden cytoreduction in preparation for HDC with ASCT (HDC-ASCT). [10]

RICE: Rituximab 375 mg/m2 day 1 plus ifosfamide 5 g/m2 on day 2 plus carboplatin AUC 5 plus etoposide 100 mg/m2 daily on days 1-3; every 14 d [11] (see also the Carboplatin AUC Dose Calculation [Calvert formula] calculator) or

ICE: Ifosfamide 5 g/m2 on day 2 plus  carboplatin AUC 5 plus  etoposide 100 mg/ m2 daily on days 1-3; every 14d [12] or

GDP: Gemcitabine 1000 mg/m2 on days 1 and 8 plus  dexamethasone 40 mg on days 1-4 plus cisplatin 75 mg/m2 on day 1; every 21d [13] or

GEM-P: Gemcitabine 1000 mg/m2 on days 1 and 8 plus methylprednisolone 1000 mg/m2 on days 1-5 plus  cisplatin 100 mg/m2 on day 15; every 28 d [14, 15] or

Gem-P: Gemcitabine 1000 mg/m2 on days 1 and 8 plus  cisplatin 100 mg/m2 on day 1; every 21d [16, 17] or

R+GEMOX: Rituximab 375 mg/m2 plus  gemcitabine 1000 mg/m2 plus oxaliplatin 100 mg/m2 on day 1; every 14 d [17] or

ESHAP: Etoposide 40 mg/m2/day plus  methylprednisolone 500 mg/day plus  cisplatin 25 mg/m2/day by continuous IV infusion (CIVI) for 4 d  plus cytarabine (Ara-C) 2 g/m2 on day 5 [18] or

DHAP: Dexamethasone 40 mg on days 1-4 plus  cytarabine 2 g/m2 every 12h for 2 doses on day 2 plus  cisplatin 100 mg/m2 on day 1; every 21d [19] or

R-DHAP: Dexamethasone 40 mg on days 1-4 plus  cytarabine 2 g/m2 every 12h for 2 doses on day 2 plus  cisplatin 100 mg/m2 on day 3; every 21 d plus  rituximab 375 mg/m2 weekly for 4 wk starting on day 1 of first cycle [20] or

R-DHAP-VIM-DHAP: Cisplatin 100 mg/m2 on day 1 by continuous IV infusion plus  cytarabine 2 g/m2 every 12 h for 2 doses on day 2 plus  dexamethasone 40 mg/day on days 1-4; VIM = etoposide 90 mg/m2 on days 1, 3, and 5 plus  ifosfamide 1200 mg/m2 IV on days 1-5 plus  methotrexate 30 mg/m2 IV on days 1 and 5; rituximab 375 mg/m2 is administered on day 5 of the DHAP courses or on day 6 of the VIM course [21] or

DHAP-VIM-DHAP: Cisplatin 100 mg/m2 on day 1 by continuous IV infusion plus  cytarabine 2 g/m2 every 12 h for 2 doses on day 2 plus  dexamethasone 40 mg/day on days 1-4; VIM = etoposide 90 mg/m2 on days 1, 3, and 5 plus  ifosfamide 1200 mg/m2 IV on days 1-5 plus  methotrexate 30 mg/m2 IV on days 1 and 5 [21]

CAR T-cell therapy (treatment goal = cure):

Tisagenlecleucel 0.6-6 x 10^8 CAR-positive viable T cells/kg IV infusion at rate of 10-20 mL/min; administer 2-11 days after completing lymphodepleting chemotherapy [34, 35]

Axicabtagene ciloleucel 2 x 10^6 CAR-positive viable T cells/kg body weight, not to exceed 2 x 10^8 CAR-positive viable T cells; infuse IV over 30 min 3 days after completing lymphodepleting chemotherapy [36]

Patients not eligible for HDC-ASCT (treatment goal = palliation):

GV: Gemcitabine 1000 mg/m2 plus vinorelbine 30 mg/m2 on days 1 and 8; every 21 d [22] or

GVP: Gemcitabine 1000 mg/m2 plus  vinorelbine 30 mg/m2 on days 1 and 8 plus  prednisone 100 mg on days 1-8; every 21d [23] or

ViGePP: Vinorelbine 25 mg/m2 plus  gemcitabine 800 mg/m2 on days 1 and 8 plus procarbazine 100 mg/m2 on days 1-7 plus  prednisone 60 mg/m2 on days 1-15; every 28 d [24] or

IEV: Ifosfamide 2500 mg/m2 plus  etoposide 150 mg/m2 on days 1-3 plus epirubicin 100 mg/m2 on day 1; every 21 d [24, 25] or

MINE: Ifosfamide 2660 mg/m2/day on days 1-3 plus  etoposide 300 mg/m2 in 1 dose on days 1-3; followed by ifosfamide 3300mg/m2 on days 1-3 plus mitoxantrone 20 mg/m2 on day 1 if less than complete response is achieved [26] or

IVAD: Ifosfamide 1500 mg/m2plus  etoposide 100 mg/m2plus  cytarabine 100 mg/m2plus  dexamethasone 40 mg on days 1-5; every 21d [27] or

Mini-BEAM: Busulfan 60 mg/m2 on day 1 plus  etoposide 75 mg/m2 on days 2-5 plus  cytarabine 100 mg/m2 every 12h on days 2-5 plus melphalan 30 mg/m2 on day 6; every 28d [28, 29] or

EPOCH: Doxorubicin 10 mg/m2 plus  etoposide 50 mg/m2 plus  vincristine 0.4 mg/m2 by continuous IV infusion on days 2-4 plus  cyclophosphamide 750 mg/m2 on day 6 plus  prednisone 60 mg/m2 on days 1-6; every 21 d [30] or

R-EPOCH: Rituximab 375 mg/m2 IV on day 1 plus  doxorubicin 15 mg/m2 plus  etoposide 65 mg/m2 plus  vincristine 0.5 mg/day by continuous IV infusion on days 2-4 plus  cyclophosphamide 750 mg/m2 on day 5 plus  prednisone 60 mg/m2 on days 1-14; every 21d [31] or

Lenalidomide 25 mg PO on days 1-21; every 28 d until progression or unacceptable toxicity [32]

Jaffe ES. The 2008 WHO classification of lymphomas: implications for clinical practice and translational research. Hematology Am Soc Hematol Educ Program. 2009. 523-31. [Medline].

Rosenwald A, Wright G, Chan WC, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 2002 Jun 20. 346(25):1937-47. [Medline].

A predictive model for aggressive non-Hodgkin’s lymphoma. The International Non-Hodgkin’s Lymphoma Prognostic Factors Project. N Engl J Med. 1993 Sep 30. 329(14):987-94. [Medline].

Kuruvilla J, MacDonald DA, Kouroukis CT, Cheung M, Olney HJ, Turner AR, et al. Salvage chemotherapy and autologous stem cell transplantation for transformed indolent lymphoma: a subset analysis of NCIC CTG LY12. Blood. 2015 Aug 6. 126 (6):733-8. [Medline].

Persky DO, Unger JM, Spier CM, et al. Phase II study of rituximab plus three cycles of CHOP and involved-field radiotherapy for patients with limited-stage aggressive B-cell lymphoma: Southwest Oncology Group study 0014. J Clin Oncol. 2008 May 10. 26(14):2258-63. [Medline].

Pfreundschuh M, Trümper L, Osterborg A, et al. CHOP-like chemotherapy plus rituximab versus CHOP-like chemotherapy alone in young patients with good-prognosis diffuse large-B-cell lymphoma: a randomised controlled trial by the MabThera International Trial (MInT) Group. Lancet Oncol. 2006 May. 7(5):379-91. [Medline].

Coiffier B, Lepage E, Briere J, et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med. 2002 Jan 24. 346(4):235-42. [Medline].

van Besien K, Ha CS, Murphy S, et al. Risk factors, treatment, and outcome of central nervous system recurrence in adults with intermediate-grade and immunoblastic lymphoma. Blood. 1998 Feb 15. 91(4):1178-84. [Medline].

Boehme V, Zeynalova S, Kloess M, et al. Incidence and risk factors of central nervous system recurrence in aggressive lymphoma–a survey of 1693 patients treated in protocols of the German High-Grade Non-Hodgkin’s Lymphoma Study Group (DSHNHL). Ann Oncol. 2007 Jan. 18(1):149-57. [Medline].

Philip T, Guglielmi C, Hagenbeek A, et al. Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin’s lymphoma. N Engl J Med. 1995 Dec 7. 333(23):1540-5. [Medline].

Kewalramani T, Zelenetz AD, Nimer SD, et al. Rituximab and ICE as second-line therapy before autologous stem cell transplantation for relapsed or primary refractory diffuse large B-cell lymphoma. Blood. 2004 May 15. 103(10):3684-8. [Medline].

Moskowitz CH, Bertino JR, Glassman JR, et al. Ifosfamide, carboplatin, and etoposide: a highly effective cytoreduction and peripheral-blood progenitor-cell mobilization regimen for transplant-eligible patients with non-Hodgkin’s lymphoma. J Clin Oncol. 1999 Dec. 17(12):3776-85. [Medline].

Crump M, Baetz T, Couban S, et al. Gemcitabine, dexamethasone, and cisplatin in patients with recurrent or refractory aggressive histology B-cell non-Hodgkin lymphoma: a Phase II study by the National Cancer Institute of Canada Clinical Trials Group (NCIC-CTG). Cancer. 2004 Oct 15. 101(8):1835-42. [Medline].

Chau I, Harries M, Cunningham D, et al. Gemcitabine, cisplatin and methylprednisolone chemotherapy (GEM-P) is an effective regimen in patients with poor prognostic primary progressive or multiply relapsed Hodgkin’s and non-Hodgkin’s lymphoma. Br J Haematol. 2003 Mar. 120(6):970-7. [Medline].

Barton S, Hawkes EA, Cunningham D, Peckitt C, Chua S, Wotherspoon A, et al. Rituximab, Gemcitabine, Cisplatin and Methylprednisolone (R-GEM-P) is an effective regimen in relapsed diffuse large B-cell lymphoma. Eur J Haematol. 2015 Mar. 94 (3):219-26. [Medline].

Ng M, Waters J, Cunningham D, et al. Gemcitabine, cisplatin and methylprednisolone (GEM-P) is an effective salvage regimen in patients with relapsed and refractory lymphoma. Br J Cancer. 2005 Apr 25. 92(8):1352-7. [Medline].

López A, Gutiérrez A, Palacios A, et al. GEMOX-R regimen is a highly effective salvage regimen in patients with refractory/relapsing diffuse large-cell lymphoma: a phase II study. Eur J Haematol. 2008 Feb. 80(2):127-32. [Medline].

Soussain C, Souleau B, Gabarre J, et al. Intensive chemotherapy with hematopoietic cell transplantation after ESHAP therapy for relapsed or refractory non-Hodgkin’s lymphoma. Results of a single-centre study of 65 patients. Leuk Lymphoma. 1999 May. 33(5-6):543-50. [Medline].

Olivieri A, Brunori M, Capelli D, et al. Salvage therapy with an outpatient DHAP schedule followed by PBSC transplantation in 79 lymphoma patients: an intention to mobilize and transplant analysis. Eur J Haematol. 2004 Jan. 72(1):10-7. [Medline].

Witzig TE, Geyer SM, Kurtin PJ, et al. Salvage chemotherapy with rituximab DHAP for relapsed non-Hodgkin lymphoma: a phase II trial in the North Central Cancer Treatment Group. Leuk Lymphoma. 2008 Jun. 49(6):1074-80. [Medline].

Vellenga E, van Putten WL, van ‘t Veer MB, et al. Rituximab improves the treatment results of DHAP-VIM-DHAP and ASCT in relapsed/progressive aggressive CD20+ NHL: a prospective randomized HOVON trial. Blood. 2008 Jan 15. 111(2):537-43. [Medline].

Papageorgiou ES, Tsirigotis P, Dimopoulos M, et al. Combination chemotherapy with gemcitabine and vinorelbine in the treatment of relapsed or refractory diffuse large B-cell lymphoma: a phase-II trial by the Hellenic Cooperative Oncology Group. Eur J Haematol. 2005 Aug. 75(2):124-9. [Medline].

Müller-Beissenhirtz H, Kasper C, et al. Gemcitabine, vinorelbine and prednisone for refractory or relapsed aggressive lymphoma, results of a phase II single center study. Ann Hematol. 2005 Nov. 84(12):796-801. [Medline].

Di Renzo N, Brugiatelli M, Montanini A, et al. Vinorelbine, gemcitabine, procarbazine and prednisone (ViGePP) as salvage therapy in relapsed or refractory aggressive non-Hodgkin’s lymphoma (NHL): results of a phase II study conducted by the Gruppo Italiano per lo Studio dei Linfomi. Leuk Lymphoma. 2006. 47:473-9.

Pocali B, De Simone M, Annunziata M, et al. Ifosfamide, epirubicin and etoposide (IEV) regimen as salvage and mobilization therapy for refractory or early relapsing patients with aggressive non-Hodgkin’s lymphoma. Leuk Lymphoma. 2004. 45:1605-9.

van Besien K, Rodriguez A, Tomany S, et al. Phase II study of a high-dose ifosfamide-based chemotherapy regimen with growth factor rescue in recurrent aggressive NHL. High response rates and limited toxicity, but limited impact on long-term survival. Bone Marrow Transplant. 2001. 27:397-404.

Schütt P, Passon J, Ebeling P, et al. Ifosfamide, etoposide, cytarabine, and dexamethasone as salvage treatment followed by high-dose cyclophosphamide, melphalan, and etoposide with autologous peripheral blood stem cell transplantation for relapsed or refractory lymphomas. Eur J Haematol. 2007 Feb. 78(2):93-101. [Medline].

Girouard C, Dufresne J, Imrie K, et al. Salvage chemotherapy with mini-BEAM for relapsed or refractory non-Hodgkin’s lymphoma prior to autologous bone marrow transplantation. Ann Oncol. 1997 Jul. 8(7):675-80. [Medline].

Nieto Y, Valdez BC, Thall PF, Ahmed S, Jones RB, Hosing C, et al. Vorinostat Combined with High-Dose Gemcitabine, Busulfan, and Melphalan with Autologous Stem Cell Transplantation in Patients with Refractory Lymphomas. Biol Blood Marrow Transplant. 2015 Nov. 21 (11):1914-20. [Medline].

Wilson WH, Bryant G, Bates S, et al. EPOCH chemotherapy: toxicity and efficacy in relapsed and refractory non-Hodgkin’s lymphoma. J Clin Oncol. 1993 Aug. 11(8):1573-82. [Medline].

Jermann M, Jost LM, Taverna Ch, et al. Rituximab-EPOCH, an effective salvage therapy for relapsed, refractory or transformed B-cell lymphomas: results of a phase II study. Ann Oncol. 2004 Mar. 15(3):511-6. [Medline].

Witzig TE, Vose JM, Luigi Zinzani P, et al. An international phase II trial of single-agent lenalidomide for relapsed or refractory aggressive B-cell non-Hodgkin’s lymphoma. Ann Oncol. 2011 Jan 12. [Epub ahead of print].

Jia B, Shi Y, Kang S, Yang S, Hu S, Li Y, et al. Addition of rituximab is not associated with survival benefit compared with CHOP alone for patients with stage I diffuse large B-cell lymphoma. Chin J Cancer Res. 2015 Oct. 27 (5):516-23. [Medline].

Schuster S, et al. Primary Analysis of Juliet: A Global, Pivotal, Phase 2 Trial of CTL019 in Adult Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma. 59th American Society of Hematology Annual Meeting and Exposition. Abstract #577. Atlanta, GA. December 9-12, 2017.

Schuster SJ, Svoboda J, Chong EA, Nasta SD, Mato AR, Anak Ö, et al. Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas. N Engl J Med. 2017 Dec 28. 377 (26):2545-2554. [Medline].

Neelapu SS, Locke FL, Bartlett NL, Lekakis LJ, Miklos DB, Jacobson CA, et al. Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma. N Engl J Med. 2017 Dec 28. 377 (26):2531-2544. [Medline].

Francisco J Hernandez-Ilizaliturri, MD Professor of Medicine, Department of Medical Oncology, Associate Professor of Immunology, Department of Immunology, Chief, Lymphoma and Myeloma Section, Director, The Lymphoma Translational Research Program, Roswell Park Cancer Institute, University of Buffalo State University of New York School of Medicine and Biomedical Sciences

Francisco J Hernandez-Ilizaliturri, MD is a member of the following medical societies: American Association for Cancer Research, American Society of Hematology

Disclosure: Nothing to disclose.

Mary L Windle, PharmD Adjunct Associate Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference

Disclosure: Nothing to disclose.

Christopher D Braden, DO Hematologist/Oncologist, Chancellor Center for Oncology at Deaconess Hospital; Medical Director, Deaconess Hospital Outpatient Infusion Centers; Chairman, Deaconess Hospital Cancer Committee

Christopher D Braden, DO is a member of the following medical societies: American Society of Clinical Oncology, American Society of Hematology

Disclosure: Nothing to disclose.

Koyamangalath Krishnan, MD, FRCP, FACP Dishner Endowed Chair of Excellence in Medicine, Professor of Medicine, James H Quillen College of Medicine at East Tennessee State University

Koyamangalath Krishnan, MD, FRCP, FACP is a member of the following medical societies: Alpha Omega Alpha, American College of Physicians-American Society of Internal Medicine, American Society of Hematology, Royal College of Physicians

Disclosure: Nothing to disclose.

Diffuse Large B-Cell Lymphoma (Non-Hodgkin Lymphoma) Treatment Protocols 

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