Male Urethritis
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Urethral discharge, dysuria, and exposure to a sexually transmitted infection (STI) are frequent presentations of urethritis in the male population. Recent research has focused on cost-effective antibiotic therapy and concern for emergence of antibiotic resistance among both typical and atypical organisms. The goal of initial therapy is to optimize compliance and prevent recurrence of this disease, which is predominantly sexually transmitted. [1, 2, 3, 4, 5, 6, 7, 8]
Inflammation of the urethra is more frequently infectious than posttraumatic, with STIs being the most common cause. Sexually transmitted urethritis is classified as either gonococcal urethritis (GCU) following infection with Neisseria gonorrhoeae, or nongonococcal urethritis (NGU).
For cases of NGU, Chlamydia trachomatis remains a primary concern, although Mycoplasma genitalium and Trichomonas vaginalis are increasingly recognized as important pathogens, and less commonly Ureaplasma parvum, Ureaplasma urealyticum, Mycoplasma hominis, and Gardnerella vaginalis. [9, 10, 11]
In one study of 424 men with signs and symptoms of acute urthritis, 127 (30%) were found to be infected with N gonorrhoeae. In 297 men with nongonococcal urethritis, C trachomatis was detected in 143 (48.1%). In 154 men with nonchlamydial nongonococcal urethritis, M genitalium (22.7%), M hominis (5.8%), U parvum (9.1%), U urealyticum (19.5%), H influenzae (14.3%), N meningitidis (3.9%), T vaginalis (1.3%), human adenovirus (16.2%), and herpes simplex virus types 1 (7.1%) and 2 (2.6%) were detected. [12]
M genitalium, not routinely tested by polymerase chain reaction (PCR) in many locations, may cause up to 10-30% of NGU cases [1, 2, 13] and, like chlamydia, may be associated with human immunodeficiency virus (HIV), human papilloma virus (HPV), and herpes simplex transmission and infection. M genitalium has been associated with treatment failure to presently recommended single-dose therapy, owing to macrolide resistance, [14, 15, 3, 16, 13, 17, 4] and has potential for quinolone resistance as well. [16, 4, 18, 15] Couldwell et al describe rates of resistance of 15% for quinolones and 43% for macrolides among 143 M genitalium specimens in Australia in 2013. [16]
Idiopathic urethritis, defined as urethritis in the absence of nucleic acid amplification testing (NAAT) evidence for the most common infectious causes (N gonorrhoeae, C trachomatis, M genitalium, and T vaginalis), may be considered the largest category. [19, 20]
Unusual infectious causes of urethritis include herpes genitalis, syphilis, mycobacterium, adenovirus, cytomegalovirus, as well as typical bacteria (usually gram-negative rods) associated with cystitis in the presence of urethral stricture or following insertive anal sex.
Urethritis following trauma is less common, but it can occur with intermittent catheterization or after urethral instrumentation or foreign body insertion. Fewer than 20% of patients practicing intermittent catheterization suffer urethritis; however, use of latex instead of silicone catheters significantly increases this risk. Symptoms of urethritis (urethral syndrome) can also be due to sensitivity to chemicals in spermicidal or contraceptive jellies or foams.
Idiopathic urethritis of childhood is of uncertain cause, perhaps related to dysfunctional elimination syndrome, [21] and presents as blood-stained urethral discharge, bleeding between micturition, or dysuria in the 5- to 15-year-old male, and can result in urethral stricture. [22, 23]
Urethritis involves local mucous membrane epithelial cell damage or invasion by an infectious agent (bacterial, viral, or fungal) followed by inflammatory changes including accumulation of leukocytes and chemical mediators (antibodies, cytokines, and interleukins) with resultant swelling, discharge, and pain.
Urethritis usually resolves without complication, even if untreated, yet it can result in urethral stricture, stenosis, or abscess formation in rare cases. Urethritis can occur in a continuum with concomitant seminal vesiculitis and epididymitis. [24]
Recurrent urethritis may occur from reinfection, therapeutic failure or “venereophobia,” an old term describing fear of recurrence where men can induce urethral inflammation and drainage (negative by white blood cell or Gram stain criteria) by repeatedly milking the urethra checking for infection. [25] .
Urethritis is predominantly a disease of adolescent and adult men. The prevalence is greatest in men younger than 25 years.
Schwebke JR, Rompalo A, Taylor S, Seña AC, Martin DH, Lopez LM, et al. Re-evaluating the treatment of nongonococcal urethritis: emphasizing emerging pathogens–a randomized clinical trial. Clin Infect Dis. 2011 Jan 15. 52(2):163-70. [Medline]. [Full Text].
Seña A, Lensing S, Rompalo A, Taylor S, Martin D, Lopez L. Chlamydia trachomatis, Mycoplasma genitalium, and Trichomonas vaginalis infections in men with non-gonococcal urethritis: predictors and persistence after therapy. J Infect Dis. 2012 May 21. [Medline].
Pond MJ, Nori AV, Witney AA, Lopeman RC, Butcher PD, Sadiq ST. High Prevalence of Antibiotic-Resistant Mycoplasma genitalium in Nongonococcal Urethritis: The Need for Routine Testing and the Inadequacy of Current Treatment Options. Clin Infect Dis. 2014 Jan 2. [Medline].
Manhart LE, Gillespie CW, Lowens MS, Khosropour CM, Colombara DV, Golden MR, et al. Standard treatment regimens for nongonococcal urethritis have similar but declining cure rates: a randomized controlled trial. Clin Infect Dis. 2013 Apr. 56(7):934-42. [Medline]. [Full Text].
Manhart LE, Broad JM, Golden MR. Mycoplasma genitalium: should we treat and how?. Clin Infect Dis. 2011 Dec. 53 Suppl 3:S129-42. [Medline]. [Full Text].
Takahashi S, Ichihara K, Hashimoto J, Kurimura Y, Iwasawa A, Hayashi K, et al. Clinical efficacy of levofloxacin 500 mg once daily for 7 days for patients with non-gonococcal urethritis. J Infect Chemother. 2011 Jun. 17(3):392-6. [Medline].
Bachmann LH, Manhart LE, Martin DH, Seña AC, Dimitrakoff J, Jensen JS, et al. Advances in the Understanding and Treatment of Male Urethritis. Clin Infect Dis. 2015 Dec 15. 61 Suppl 8:S763-9. [Medline].
Horner P, Blee K, O’Mahony C, Muir P, Evans C, Radcliffe K, et al. 2015 UK National Guideline on the management of non-gonococcal urethritis. Int J STD AIDS. 2016 Feb. 27 (2):85-96. [Medline].
Gaydos CA, Maldeis N, Hardick A, Hardick J, Quinn TC. Mycoplasma genitalium Compared to Chlamydia, Gonorrhea, and Trichomonas as an Etiologic Agent of Urethritis in Men Attending STD Clinics. Sex Transm Infect. 2009 Apr 20. [Medline].
Iser P, Read TH, Tabrizi S, Bradshaw C, Lee D, Horvarth L, et al. Symptoms of non-gonococcal urethritis in heterosexual men: a case control study. Sex Transm Infect. 2005 Apr. 81(2):163-5. [Medline].
Moi H, Reinton N, Moghaddam A. Mycoplasma genitalium is associated with symptomatic and asymptomatic non-gonococcal urethritis in men. Sex Transm Infect. 2009 Feb. 85(1):15-8. [Medline].
Ito S, Hanaoka N, Shimuta K, Seike K, Tsuchiya T, Yasuda M, et al. Male non-gonococcal urethritis: From microbiological etiologies to demographic and clinical features. Int J Urol. 2016 Feb 4. [Medline].
Hamasuna R. Mycoplasma genitalium in male urethritis: diagnosis and treatment in Japan. Int J Urol. 2013 Jul. 20(7):676-84. [Medline].
Chrisment D, Charron A, Cazanave C, Pereyre S, Bébéar C. Detection of macrolide resistance in Mycoplasma genitalium in France. J Antimicrob Chemother. 2012 Nov. 67(11):2598-601. [Medline].
Horner P, Blee K, Adams E. Time to manage Mycoplasma genitalium as an STI: but not with azithromycin 1?g!. Curr Opin Infect Dis. 2014 Feb. 27(1):68-74. [Medline].
Couldwell DL, Tagg KA, Jeoffreys NJ, Gilbert GL. Failure of moxifloxacin treatment in Mycoplasma genitalium infections due to macrolide and fluoroquinolone resistance. Int J STD AIDS. 2013 Oct. 24(10):822-8. [Medline].
Ito S, Yasuda M, Seike K, Sugawara T, Tsuchiya T, Yokoi S, et al. Clinical and microbiological outcomes in treatment of men with non-gonococcal urethritis with a 100-mg twice-daily dose regimen of sitafloxacin. J Infect Chemother. 2012 Jun. 18(3):414-8. [Medline].
Weinstein SA, Stiles BG. Recent perspectives in the diagnosis and evidence-based treatment of Mycoplasma genitalium. Expert Rev Anti Infect Ther. 2012 Apr. 10(4):487-99. [Medline].
Wetmore CM, Manhart LE, Golden MR. Idiopathic urethritis in young men in the United States: prevalence and comparison to infections with known sexually transmitted pathogens. J Adolesc Health. 2009 Nov. 45(5):463-72. [Medline]. [Full Text].
Wetmore CM, Manhart LE, Lowens MS, Golden MR, Whittington WL, Xet-Mull AM, et al. Demographic, behavioral, and clinical characteristics of men with nongonococcal urethritis differ by etiology: a case-comparison study. Sex Transm Dis. 2011 Mar. 38(3):180-6. [Medline].
Herz D, Weiser A, Collette T, Reda E, Levitt S, Franco I. Dysfunctional elimination syndrome as an etiology of idiopathic urethritis in childhood. J Urol. 2005 Jun. 173(6):2132-7. [Medline].
Eradi B, Ninan GK. Intravesical steroid instillation–a novel therapeutic intervention for idiopathic urethritis of childhood. Eur J Pediatr Surg. 2009 Apr. 19(2):105-7. [Medline].
Henderson L, Farrelly P, Dickson AP, Goyal A. Management strategies for idiopathic urethritis. J Pediatr Urol. 2016 Feb. 12 (1):35.e1-5. [Medline].
Furuya R, Takahashi S, Furuya S, Saitoh N, Ogura H, Kurimura Y, et al. Is urethritis accompanied by seminal vesiculitis?. Int J Urol. 2009 Jul. 16(7):628-31. [Medline].
Shahmanesh M, Moi H, Lassau F, Janier M. 2009 European guideline on the management of male non-gonococcal urethritis. Int J STD AIDS. 2009 Jul. 20(7):458-64. [Medline].
Gillespie CW, Manhart LE, Lowens MS, Golden MR. Asymptomatic urethritis is common and is associated with characteristics that suggest sexually transmitted etiology. Sex Transm Dis. 2013 Mar. 40(3):271-4. [Medline].
Kim SJ, Lee DS, Lee SJ. The prevalence and clinical significance of urethritis and cervicitis in asymptomatic people by use of multiplex polymerase chain reaction. Korean J Urol. 2011 Oct. 52(10):703-8. [Medline]. [Full Text].
Tuddenham S, Ghanem KG. Toward enhancing sexually transmitted infection clinic efficiency in an era of molecular diagnostics: the role of physical examination and risk stratification in men. Sex Transm Dis. 2013 Nov. 40(11):886-93. [Medline].
Horner PJ, Taylor-Robinson D. Association of Mycoplasma genitalium with balanoposthitis in men with non-gonococcal urethritis. Sex Transm Infect. 2011 Feb. 87(1):38-40. [Medline].
Frolund M, Lidbrink P, Wikstrom A, Cowan S, Ahrens P, Skov Jensen J. Urethritis-associated Pathogens in Urine from Men with Non-gonococcal Urethritis: A Case-control Study. Acta Derm Venereol. 2015 Dec 11. [Medline].
Mezzini TM, Waddell RG, Douglas RJ, Sadlon TA. Mycoplasma genitalium: prevalence in men presenting with urethritis to a South Australian public sexual health clinic. Intern Med J. 2013 May. 43(5):494-500. [Medline].
Shimada Y, Ito S, Mizutani K, Sugawara T, Seike K, Tsuchiya T, et al. Bacterial loads of Ureaplasma urealyticum contribute to development of urethritis in men. Int J STD AIDS. 2013 Sep 18. [Medline].
Lewis DA, Marsh K, Radebe F, Maseko V, Hughes G. Trends and associations of Trichomonas vaginalis infection in men and women with genital discharge syndromes in Johannesburg, South Africa. Sex Transm Infect. 2013 Sep. 89(6):523-7. [Medline].
Henderson L, Farrelly P, Dickson AP, Goyal A. Management strategies for idiopathic urethritis. J Pediatr Urol. 2016 Feb. 12 (1):35.e1-5. [Medline].
Kirsch TD, Shesser R, Barron M. Disease surveillance in the ED: factors leading to the underreporting of gonorrhea. Am J Emerg Med. 1998 Mar. 16(2):137-40. [Medline].
[Guideline] CDC. 2006 guidelines for treatment of sexually transmitted diseases. Centers for Disease Control and Prevention. MMWR Morb Mortal Wkly Rep. 55(RR-11):1-94. [Full Text].
[Guideline] CDC, Workowski KA, Berman SM. Sexually transmitted diseases treatment guidelines, 2006. MMWR Recomm Rep. 2006 Aug 4. 55(RR-11):1-94. [Medline].
Orellana MA, Gómez-Lus ML, Lora D. Sensitivity of Gram stain in the diagnosis of urethritis in men. Sex Transm Infect. 2012 Feb 2. [Medline].
Rietmeijer CA, Mettenbrink CJ. Recalibrating the Gram stain diagnosis of male urethritis in the era of nucleic acid amplification testing. Sex Transm Dis. 2012 Jan. 39(1):18-20. [Medline].
Kwan B, Ryder N, Knight V, Kenigsberg A, McNulty A, Read P, et al. Sensitivity of 20-minute voiding intervals in men testing for Chlamydia trachomatis. Sex Transm Dis. 2012 May. 39(5):405-6. [Medline].
Hobbs MM, Lapple DM, Lawing LF, Schwebke JR, Cohen MS, Swygard H, et al. Methods for detection of Trichomonas vaginalis in the male partners of infected women: implications for control of trichomoniasis. J Clin Microbiol. 2006 Nov. 44(11):3994-9. [Medline].
Yasuda M, Ito S, Kido A, Hamano K, Uchijima Y, Uwatoko N, et al. A single 2 g oral dose of extended-release azithromycin for treatment of gonococcal urethritis. J Antimicrob Chemother. 2014 Nov. 69 (11):3116-8. [Medline].
Costa LM, Pedroso ER, Vieira Neto V, Souza VC, Teixeira MJ. Antimicrobial susceptibility of Neisseria gonorrhoeae isolates from patients attending a public referral center for sexually transmitted diseases in Belo Horizonte, State of Minas Gerais, Brazil. Rev Soc Bras Med Trop. 2013 May-Jun. 46(3):304-9. [Medline].
Yuan LF, Yin YP, Dai XQ, Pearline RV, Xiang Z, Unemo M, et al. Resistance to azithromycin of Neisseria gonorrhoeae isolates from 2 cities in China. Sex Transm Dis. 2011 Aug. 38(8):764-8. [Medline].
Chen PL, Hsieh YH, Lee HC, et al. Suboptimal therapy and clinical management of gonorrhoea in an area with high-level antimicrobial resistance. Int J STD AIDS. 2009 Apr. 20(4):225-8. [Medline].
CDC. Update to CDC’s Sexually transmitted diseases treatment guidelines, 2006: fluoroquinolones no longer recommended for treatment of gonococcal infections. MMWR. Apr 13 2007. 56(14):332-334. [Full Text].
Mena LA, Mroczkowski TF, Nsuami M, Martin DH. A randomized comparison of azithromycin and doxycycline for the treatment of Mycoplasma genitalium-positive urethritis in men. Clin Infect Dis. 2009 Jun 15. 48(12):1649-54. [Medline].
Falk L, Fredlund H, Jensen JS. Tetracycline treatment does not eradicate Mycoplasma genitalium. Sex Transm Infect. 2003 Aug. 79(4):318-9. [Medline].
Jensen JS, Bradshaw CS, Tabrizi SN, Fairley CK, Hamasuna R. Azithromycin treatment failure in Mycoplasma genitalium-positive patients with nongonococcal urethritis is associated with induced macrolide resistance. Clin Infect Dis. 2008 Dec 15. 47(12):1546-53. [Medline].
Lau A, Bradshaw CS, Lewis D, Fairley CK, Chen MY, Kong FY, et al. The Efficacy of Azithromycin for the Treatment of Genital Mycoplasma genitalium: A Systematic Review and Meta-analysis. Clin Infect Dis. 2015 Nov 1. 61 (9):1389-99. [Medline].
Moi H, Blee K, Horner PJ. Management of non-gonococcal urethritis. BMC Infect Dis. 2015 Jul 29. 15:294. [Medline].
Maeda S, Yasuda M, Ito S, Seike K, Ito S, Deguchi T. Azithromycin treatment for nongonococcal urethritis negative for Chlamydia trachomatis, Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum. Int J Urol. 2009 Feb. 16(2):215-6. [Medline].
Takahashi S, Matsukawa M, Kurimura Y, et al. Clinical efficacy of azithromycin for male nongonococcal urethritis. J Infect Chemother. 2008 Dec. 14(6):409-12. [Medline].
Bradshaw CS, Chen MY, Fairley CK. Persistence of Mycoplasma genitalium following azithromycin therapy. PLoS One. 2008. 3(11):e3618. [Medline]. [Full Text].
Bradshaw CS, Jensen JS, Tabrizi SN, Read TR, Garland SM, Hopkins CA, et al. Azithromycin failure in Mycoplasma genitalium urethritis. Emerg Infect Dis. 2006 Jul. 12(7):1149-52. [Medline].
Jernberg E, Moghaddam A, Moi H. Azithromycin and moxifloxacin for microbiological cure of Mycoplasma genitalium infection: an open study. Int J STD AIDS. 2008 Oct. 19(10):676-9. [Medline].
Khosropour CM, Manhart LE, Colombara DV, Gillespie CW, Lowens MS, Totten PA, et al. Suboptimal adherence to doxycycline and treatment outcomes among men with non-gonococcal urethritis: a prospective cohort study. Sex Transm Infect. 2013 Oct 8. [Medline].
Wikstrom A, Jensen JS. Mycoplasma genitalium: a common cause of persistent urethritis among men treated with doxycycline. Sex Transm Infect. 2006 Aug. 82(4):276-9. [Medline]. [Full Text].
Deguchi T, Ito S, Hagiwara N, Yasuda M, Maeda S. Antimicrobial chemotherapy of Mycoplasma genitalium-positive non-gonococcal urethritis. Expert Rev Anti Infect Ther. 2012 Jul. 10(7):791-803. [Medline].
Hamasuna R, Takahashi S, Uehara S, Matsumoto T. Should urologists care for the pharyngeal infection of Neisseria gonorrhoeae or Chlamydia trachomatis when we treat male urethritis?. J Infect Chemother. 2012 Feb 4. [Medline].
Shigehara K, Kawaguchi S, Sasagawa T, Furubayashi K, Shimamura M, Maeda Y, et al. Prevalence of genital Mycoplasma, Ureaplasma, Gardnerella, and human papillomavirus in Japanese men with urethritis, and risk factors for detection of urethral human papillomavirus infection. J Infect Chemother. 2011 Aug. 17(4):487-92. [Medline].
Hamasuna R, Yasuda M, Ishikawa K, Uehara S, Takahashi S, Hayami H, et al. Nationwide surveillance of the antimicrobial susceptibility of Neisseria gonorrhoeae from male urethritis in Japan. J Infect Chemother. 2013 Aug. 19(4):571-8. [Medline].
Lau CY, Qureshi AK. Azithromycin versus doxycycline for genital chlamydial infections: a meta-analysis of randomized clinical trials. Sex Transm Dis. 2002 Sep. 29(9):497-502. [Medline].
Lyss SB, Kamb ML, Peterman TA, et al. Chlamydia trachomatis among patients infected with and treated for Neisseria gonorrhoeae in sexually transmitted disease clinics in the United States. Ann Intern Med. 2003 Aug 5. 139(3):178-85. [Medline].
Michael C Plewa, MD Research Director, Department of Emergency Medicine, Mercy Emergency Care Services, Inc, and Mercy Health Saint Vincent Medical Center
Michael C Plewa, MD is a member of the following medical societies: American College of Emergency Physicians, American Academy of Emergency Medicine, American Medical Association, Physicians for Social Responsibility, Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.
Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug Reference
Disclosure: Received salary from Medscape for employment. for: Medscape.
Richard H Sinert, DO Professor of Emergency Medicine, Clinical Assistant Professor of Medicine, Research Director, State University of New York College of Medicine; Consulting Staff, Vice-Chair in Charge of Research, Department of Emergency Medicine, Kings County Hospital Center
Richard H Sinert, DO is a member of the following medical societies: American College of Physicians, Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.
Erik D Schraga, MD Staff Physician, Department of Emergency Medicine, Mills-Peninsula Emergency Medical Associates
Disclosure: Nothing to disclose.
David S Howes, MD Professor of Medicine and Pediatrics, Residency Program Director Emeritus, Section of Emergency Medicine, University of Chicago, University of Chicago, The Pritzker School of Medicine
David S Howes, MD is a member of the following medical societies: American Academy of Emergency Medicine, American College of Emergency Physicians, Society for Academic Emergency Medicine
Disclosure: Nothing to disclose.
Male Urethritis
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