Progressive supranuclear palsy
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Deterioration of cells in the brainstem, cerebral cortex, cerebellum and basal ganglia — a cluster of cells deep within your brain — is what causes the coordination and movement issues of progressive supranuclear palsy.
Progressive supranuclear palsy, also called Steele-Richardson-Olszewski syndrome, is an uncommon brain disorder that causes serious problems with walking, balance and eye movements. The disorder results from deterioration of cells in areas of your brain that control body movement and thinking.
Progressive supranuclear palsy worsens over time and can lead to life-threatening complications, such as pneumonia and swallowing problems. There’s no cure for progressive supranuclear palsy, so treatment focuses on managing the signs and symptoms.
Progressive supranuclear palsy care at Mayo Clinic
The characteristic signs and symptoms of progressive supranuclear palsy include:
Additional signs and symptoms of progressive supranuclear palsy vary and may mimic those of Parkinson’s disease and dementia. These signs and symptoms worsen as the disease advances, and may include:
Make an appointment with your doctor if you experience signs and symptoms of progressive supranuclear palsy.
The cause of progressive supranuclear palsy isn’t known. The signs and symptoms of the disorder result from deterioration of cells in areas of your brain, especially those that help you control body movements (midbrain) and thinking (frontal lobe).
Researchers have found that the deteriorating brain cells of people with progressive supranuclear palsy have abnormal amounts of a protein called tau. Clumps of tau are also characteristic of other neurodegenerative disorders, such as Alzheimer’s disease.
Rarely, progressive supranuclear palsy occurs within a family. But a genetic link isn’t clear, and most people with progressive supranuclear palsy haven’t inherited the disorder.
The only proven risk factor for progressive supranuclear palsy is age. The condition typically affects people around the age of 60, and is virtually unknown in people under the age of 40.
Complications of progressive supranuclear palsy result primarily from hindered muscle movements. These complications may include:
To avoid the hazards of choking, your doctor may recommend a feeding tube. To avoid injuries due to falling, a walker or a wheelchair may be used.
Progressive supranuclear palsy care at Mayo Clinic
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Progressive supranuclear palsy
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