Undifferentiated pleomorphic sarcoma

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Undifferentiated pleomorphic sarcoma

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Undifferentiated pleomorphic sarcoma (UPS), formerly referred to as malignant fibrous histiocytoma, is a type of soft tissue cancer. The word “undifferentiated” in undifferentiated pleomorphic sarcoma means that the cells don’t resemble the body tissues in which they develop. The cancer is called pleomorphic (plee-o-MOR-fik) because the cells grow in multiple shapes and sizes.

While sarcomas are not common tumors, they do represent one of the most common soft tissue malignancies in adults. Soft tissue sarcomas can develop in blood vessels and in deep skin, fat, muscle, fibrous or nerve tissues.

In particular, UPS usually occurs in the arms or legs, and somewhat less often in the area behind the abdominal cavity (retroperitoneum). The cancer typically becomes quite large over a period of weeks or months, sometimes growing quite rapidly. In most cases, only a rapidly growing UPS causes noticeable pain. Although it tends to grow locally, the cancer can spread to other locations in the body, most often the lungs.

Undifferentiated pleomorphic sarcoma is called a diagnosis of exclusion, meaning it’s agreed upon when other diagnoses have been ruled out; it represents less than 5 percent of adult sarcomas.

Make an appointment with a doctor if you develop any signs or symptoms that seem unusual or that worry you:

Most often these signs and symptoms come from some other issue than sarcoma, but consult with your doctor regardless.

Although the causes of UPS are largely unknown, a small percentage (less than 2 to 3 percent) develops at the site of previous radiation therapy. In very rare cases, the sarcoma can also develop in or around chronic ulcers or tissue scarring. A specific cause isn’t often identified for most UPS.

Most undifferentiated pleomorphic sarcomas develop in people with no known risk factors. However, some factors may increase their likelihood, including radiation, a damaged lymph system and exposure to certain chemicals.

Again, most people who develop undifferentiated pleomorphic sarcoma have no known risk factors, and many people who have risk factors never develop the cancer.

Undifferentiated pleomorphic sarcoma care at Mayo Clinic

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Undifferentiated pleomorphic sarcoma

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Undifferentiated pleomorphic sarcoma

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